| PS2、COX2、CerbB2在乳腺癌中表达的研究 |
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| 引用本文： | 李菊英,贺菊香,苟笑丹.PS2、COX2、CerbB2在乳腺癌中表达的研究[J].中国实用医药,2010,5(11):51-53. |
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| 作者姓名： | 李菊英 贺菊香 苟笑丹 |
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| 作者单位： | 青海医学院病理教研室,西宁,810001 |
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| 摘 要： | 目的研究ER、PR与PS2、COX2、CerbB2在乳腺癌组织中的表达,探讨与病理类型、淋巴转移、内分泌治疗及预后的关系。方法采用免疫组化SP检测54例乳腺癌组织中COX2、CerbB2、PS2、ER、PR的表达。结果COX2、CerbB2在乳腺癌组织的表达的阳性率与肿瘤的大小、发病年龄肿瘤分级及淋巴转移有关,（P〈0.05）,在高分化癌中低表达,在低分化癌中高表达,在淋巴结转移组织中两者都高表达。PS2在ER、PR阳性的癌组织中高表达,与肿瘤的大小、发病年龄、淋巴结转移无明显的关系,但与肿瘤的分化程度有关,在高分化癌中高表达,在低分化癌中低表达。结论PS2、ER、PR三项指标全阳性可预测乳腺癌患者辅助内分泌治疗疗效的可靠指标;COX2、CerbB2可作为判断预后的指标。
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| 关 键 词： | 乳腺癌 PS2 CerbB2 ER PR 预后 |
PS_2,COX_2,CerbB_2 expression in breast cancer research |
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| LI Ju-qing,He Ju-xiang,GOU Xiao-dan.PS_2,COX_2,CerbB_2 expression in breast cancer research[J].China Practical Medical,2010,5(11):51-53. |
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| Authors: | LI Ju-qing He Ju-xiang GOU Xiao-dan |
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| Affiliation: | LI Ju-qing,He Ju-xiang,GOU Xiao-dan.Pathology Teaching , Research,Qinghai Medical College.Xining 810001,China |
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| Abstract: | Objective To investigate the expression of ER),(PR),PS2,COX-2and CerbB2 in breast cancer tissues and study the relate of ER,PR,PS2,COX-2 and CerbB2 With histological grade and lymph nodo metastasis and Endocrine therapy.Methods Using immunohistochemical SP method detected 54 cases of breast cancer in ER,PR,PS2,C0X-2 and CerbB2 expression.Results COX2,CerbB2 in breast cancer tissues and the positive rate of tumor size,tumor grade and age-related lymph node metastasis,(P<0.05).Well-differentiated carcinoma at... |
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| Keywords: | PS2 CerbB2 ER PR |
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