针灸疗法与西药对照治疗围绝经期失眠症疗效和安全性的系统评价

[目的]系统评价针灸疗法与口服西药对照治疗围绝经期失眠症的临床疗效和安全性.[方法]计算机检索中国知网期刊全文数据库(CNKI)、维普期刊数据库(VIP)、万方数据知识服务平台(Wanfang)、PubMed、Web of Science、Cochrane Library等数据库.搜集并筛选相关的针灸疗法与西药对照治疗...

Systematic Evaluation of Therapeutic Efficacy and Safety of Acupuncture-Moxibustion Therapy in Comparison with Western Medicine for Treatment of Perimenopausal Insomnia

Objective To systematically evaluate the clinical therapeutic efficacy and safety of acupuncturemoxibustion therapy in comparison with western medicine for the treatment of perimenopausal insomnia.Methods We searched CNKI,VIP,Wanfang,PubMed,Web of Science,Cochrane Library databases by computer to collect and screen out the literatures on related randomized controlled trials about acupuncture therapy for perimenopausal insomnia,and used RevMan 5.3 software to carry out methodological quality evaluation and metaanalysis of the included literatures.Results A total of 34 researches were included,in which 14 were of high quality,including 1459 patients in the treatment group and 1417 patients in the control group.The results showed that the improvement in total effective rate[OR=2.79,95%CI(2.22,3.50),P<0.00001],Pittsburgh Sleep Quality Index(PSQI)score[MD=-2.09,95%CI(-2.91,-1.27),P<0.00001]and modified Kupperman score[MD=-4.41,95%CI(-6.38,-2.45),P<0.00001]of the treatment group was superior to that of the control group.The results of subgroup analysis showed that the total effective rate in acupuncture alone group was significantly higher than that of the control group[OR=2.57,95%CI(1.86,3.55),P<0.00001].The incidence of adverse reactions for acupuncture-moxibustion therapy treatment was lower than the control group[RR=0.32,95%CI(0.18,0.54),P<0.0001].There were possible publication bias in the included literatures.Conclusion Acupuncture-moxibustion therapy has a better clinical efficacy and safety for perimenopausal insomnia than oral western medicine treatment.However,due to the low quality of the most included literatures,the conclusions are not particularly convinced,need to be verified by more randomized controlled trials with high quality.