合并HIV/HBV感染的肝细胞癌患者临床特征

目的 分析合并人类免疫缺陷病毒(HIV)和乙型肝炎病毒(HBV)感染的肝细胞癌患者(HIV/HBV-HCC)和非合并HIV感染的HBV相关肝细胞癌患者(HBV-HCC)临床资料,总结HIV/HBV-HCC患者临床特点,以提高对该病的认识.方法 收集2012年6月-2020年10月在广州医科大学附属市八医院首次确诊的27...

Clinical characteristics of hepatocellular carcinoma patients co-infected with HIV/HBV

Objectives To analyze and summarize the clinical characteristics of hepatocellular carcinoma patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and non-HIV infected patients with HBV-associated hepatocellular carcinoma (HBV-HCC), we summarize the clinical characteristics of HIV/HBV-HCC patients, so as to improve the understanding of the disease. Methods A total of 78 hepatocellular carcinoma (HCC) patients were enrolled in this study, including 27 HIV/HBV-HCC and 51 HBV-HCC patients hospitalized from June 2012 to October 2020 in Guangzhou Eighth People's Hospital. Clinical data were compared within the two groups using SPSS 13.0 software. Results In this study, the average age in HIV/HBV-HCC patients were younger than HBV-HCC patients (P<0.05). Among the 27 HIV/HBV-HCC patients, 12 patients (12/27, 44.4%) received antiviral therapy before the diagnosis of HCC, the mean times was 4.5(0.6-7.0) years. HIV RNA and HBV DNA were lower than detection limit in 9 and 6 patients in the diagnosis of HCC respectively. In addition, the ratio of cirrhosis was lower in HIV/HBV-HCC than HBV-HCC patients (P<0.05), however, others clinical data and the clinical staging of HCC did not differ between the two groups (P>0.05). The staging of Barcelona HCC indicated that the diagnosis of HCC was mainly advanced in both groups, and there was no significant difference in the staging of HCC between the two groups (P>0.05). Conclusion The average age was younger in HIV/HBV-HCC patients compared to HBV-HCC patients, and the HIV/HBV co-infected patients remain have the risk of developing HCC even receive effective antiviral therapy, therefore, routine screening of HCC should be performed on HIV/HBV co-infected patients to reduce the risk of developing HCC.