白内障晶体中某些微量元素、与谷胱甘肽相关酶类活性的动态观察及其相互关系

本文动态观察了用平阳霉素诱发的大鼠白内障晶体中与谷胱甘肽代谢相关酶类活性和微量元素水平的变化，并与正常晶体进行比较，同时就酶活性与微量元素水平的相关性进行了检验。结果表明：（１）注射平阳霉素早期酶活性增高，谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、谷胱甘肽还原酶（ＧＳＳＧ－Ｒ）及超氧化物歧化酶（ＳＯＤ）等活性的升高达显著水平，后期酶活性均下降，尤以ＧＳＨ－Ｐｘ、ＧＳＳＧ－Ｒ和谷胱甘肽硫转移酶（ＧＳＨ－Ｓ）等的活性降低明显；（２）ＧＳＨ－Ｐｘ和ＳＯＤ酶活性分别与Ｚｎ具有相关性（Ｐ＜０．０５），这两种酶也分别与Ｓｅ具有高度相关性（Ｐ＜０．０１），此两种元素在该类型白内障形成中可能有一定意义。

Study on Contents and Correlation between Certain Trace Elements and Activities of Enzymes Related to Glutathione in Cataractous Lenses of Rats Induced by Pingyangmycin

Activities of enzymes related to glutathione and contents of certain trace elements in cataractous lenses of rats induced by pingyangmycin have been observed continually and compared with those of normal lenses. At the same time correlation between enzyme activities and certain trace elements has been examined. The results are as follows: (1)After the injection of pingyangmycin,the activities of GSH-Px, GSSG-R and SOD are increased significantly and are higher than those of the normal lenses at the early stage; the activities of GSH-Px, GSSG-R and GSH-S are clearly decreased at the late periods.(2) The activities of GSH-Px and SOD are correlated with Zn respectively (P<0.05), and there are significant relationships of Se with GSH-Px and SOD(P<0. 01). It is certain that Zn and Se play some role in the formation of cataract.