Metastasis-related miRNAs,active players in breast cancer invasion,and metastasis |
| |
Authors: | Ming Shi Dan Liu Huijun Duan Beifen Shen Ning Guo |
| |
Affiliation: | (1) Department of Molecular Immunology, Institute of Basic Medical Sciences, Taiping Road 27, Beijing, 100850, People’s Republic of China;(2) Department of Pathology, Hebei Medical University, Shijiazhuang, 050017, People’s Republic of China; |
| |
Abstract: | Breast cancer is the most common malignancy with the highest incidence among women in the world. Metastasis is the major reason
for breast cancer-related deaths. The precise molecular circuitry that governs the metastasis process has not been completely
understood. Discoveries of microRNAs (miRNAs) open a new avenue for cancer metastasis research. It has become clear that alterations
of miRNA expression contribute to cancer pathogenesis. miRNAs control a wide array of physiological and pathological processes,
including development, differentiation, cellular proliferation, programmed cell death, oncogenesis, and metastasis by modulating
the expression of their cognate target genes through cleaving mRNA molecules or inhibiting their translation. Some miRNAs
are associated with the invasive and metastatic phenotype of breast cancer cell lines or identified in metastatic tumor tissues
and lymph nodes. Some miRNAs serve as metastasis suppressors and their expression is frequently downregulated or lost in both
breast cancer cell lines and metastatic foci. Some miRNAs are considered to play key roles in the phenotype formation of breast
cancer stem cells. This review will focus on recent discoveries related to the miRNAs involved in the metastasis of breast
cancer and discuss the implications for the diagnosis, prognosis, and therapeutic strategies of breast cancer. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|