健康成人可接受牛奶摄入量实验研究

目的找出严重乳糖不耐受者最低可接受牛奶摄入量,观察此摄入量在健康成人中的耐受情况。方法采用氢呼气试验从38名受试者中筛选出8名有水样状腹泻的乳糖不耐受者,分成低、高剂量组参加饮奶试验。两组症状评分之和大致相等,据文献报道及单因素优选法(黄金分割法)确定两组对象分别饮用25g和38.2g奶粉(分别含6.25g和9.55g乳糖)和水冲调成的200ml牛奶,分析受试者氢呼气浓度变化值、症状评分、粪便乳糖含量(醋酸铅法)。采用随机整群抽样方法选取健康的100名青年、80名中年、100名老年人,观察摄入25g奶粉后出现的耐受症状。结果两组受试者在饮奶试验中无一例腹泻发生,仅有不同程度的轻微症状;高剂量组(B组)对象饮奶后,其氢呼气浓度、症状评分、粪便乳糖均高于低剂量组(A组)。健康成人饮用25g奶粉冲调的牛奶后,80.3%的对象未产生任何乳糖不耐受症状。结论结果表明健康成人即使为乳糖不耐受者也能饮用适量牛奶,大多数健康成人摄入25g奶粉(含乳糖6.25g)后不会出现任何乳糖不耐受症状,建议20g奶粉(含乳糖5g,配成160ml牛奶)作为我国成年人的最低可接受牛奶摄入量。

Study on the lowest acceptable intake of cow''''s milk for healthy adults

Objective To find out the lowest acceptable intake of Cow's Milk in subjects with lactose intolerance(LI)and then observe intolerance symptoms in 280 healthy adults after they drank the milk.Methods Eight LI subjects with watery diarrhea who were selected from 38 subjects by hydrogen breath test(HBT) were divided into group A,group B to go on drinking cow's milk test.The subjects in group A ingested 25g milk powder,the subjects in group B ingested 38.2g milk powder(contain 6.25g,9.55g lactose respectively) according to literature and single factor optimization method(0.618 golden mean) to analyze their hydrogen excretion(ppm),symptom score and stool lactose.The 100 younger,the 80 middle-age and the 100 elder subjects were selected to observe symptoms after they ingested 25g milk powder.Results hydrogen excretion(ppm) and symptom score in the high dose group(group B)are a little higher than those in low dose group(group A). No case with diarrhea occurred in these two group but mild symptoms.Most of healthy adults(80.3%) have no intolerance symptoms after they drank the milk.Conclusion The study demonstrates that most of adults,even with LI,can tolerance 25g cow's milk powder(6.25g lactose).It is suggested 20g cow's milk powder(5g lactose,make 160ml of milk solution) is the lowest acceptable intake of healthy adults in China.