热、化疗联合治疗晚期非小细胞肺癌初探

背景与目的晚期非小细胞肺癌化疗有效率低,而热、化疗联合已在多种实体瘤的治疗中取得良好效果。本研究旨在探讨热疗与化疗联合治疗晚期非小细胞肺癌的可行性及近期疗效。方法51例晚期非小细胞肺癌患者入选,其中热化疗组(HC组)22例,单纯化疗组(C组)29例,均给予NP(长春瑞滨 顺铂)或GP(吉西他滨 顺铂)方案化疗2个周期。热化疗组使用13.8MHz局部射频热疗机同步进行热疗,每周2次,共12次。结果热化疗组有效率为22.7%,单纯化疗组为13.8%(P>0.05);热化疗组临床受益率为68.2%,而单纯化疗组为34.5%(P<0.05)。两组患者治疗前后KPS评分的变化无统计学意义。结论初步观察到热、化疗联合治疗晚期非小细胞肺癌有良好的耐受性和较好的近期疗效,值得进一步研究。

Hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer: an initial study

Background and objective The efficacy of chemotherapy alone is still unsatisfactory in the treatment of advanced non-small cell lung cancer (NSCLC). Some kinds of solid tumors have showed good responses to chemotherapy combined with hyperthermia. This study is to investigate the feasibility and the response of hyperthermia combined with chemotherapy for advanced NSCLC. Methods A total of 51 patients with advanced NSCLC were eligible, in which 22 were in group HC, and the other 29 in group C. Patients in the two groups received NP (vinorelbine cisplatin) or GP (gemcitabine cisplatin) regimen for 2 cycles. In addition, patients in group HC received local hyperthermia twice a week, up to 12 times. Results The response rate in group HC was 22.7%, and 13.8% in group C (P>0.05). The clinical benefit rate in group HC was significantly higher than that in group C (P<0.05). There was no difference in change of KPS score after treatment between the two groups. Conclusion Hyperthermia combined with chemotherapy shows good tole- rance and response in patients with advanced NSCLC. Further study should be carried out.