外周血淋巴细胞/单核细胞比值与恶性胸膜间皮瘤患者预后的关系

目的 探讨外周血淋巴细胞/单核细胞比值(LMR)与恶性胸膜间皮瘤(MPM)患者预后的关系。 方法 收集85例MPM患者的临床资料和随访资料,根据外周血LMR值将患者分为高LMR组(n=27)和低LMR组(n=58),对比分析两组临床病理资料和生存时间,并采用Cox回归模型分析LMR及其他临床病理因素与患者总生存期的关系。 结果 两组性别、功能状态(PS)评分、淋巴细胞计数和单核细胞计数差异有统计学意义(P<0.05)。高LMR组中位生存时间(27个月)显著长于低LMR组(9个月)(P<0.001)。在不同组织学类型和肿瘤分期患者中,高LMR组中位生存时间均长于低LMR组(P<0.05)。多因素分析显示,LMR是影响MPM患者总生存期的独立因素(HR: 0.277; 95% CI: 0.142~0.538; P<0.001)。 结论 外周血LMR可作为反映MPM患者生存预后的生物学标志物。

Correlation between lymphocyte-to-monocyte ratio in peripheral blood and prognosis of malignant pleural mesothelioma

Objective To explore the correlation between lymphocyte-to-monocyte ratio(LMR)in peripheral blood and prognosis of malignant pleural mesothelioma(MPM). Methods Clinicopathological data of 85 patients with MPM were retrospectively analyzed. According to the LMR in peripheral blood, the patients were divided into two groups: high LMR group(n=27)and low LMR group(n=58). The clinicopathological data and overall survival of the two groups were compared. The correlation between the clinicopathological data and the overall survival was analyzed with Cox regression model. Results Significant differences were observed between the two groups in gender, performance status(PS)score, absolute lymphocyte count and absolute monocyte count(P<0.05). The median overall survival of patients with high LMR was significantly longer than that of patients with low LMR(27 months vs 9 months, P<0.001). Of patients with various histological types and tumor stages, the median overall survival of patients with high LMR was significantly longer than that of patients with low LMR. Multivariate analysis showed that LMR was an independent prognostic factor associated with prognosis of MPM(HR: 0.277; 95% CI: 0.142-0.538; P<0.001). Conclusion LMR in peripheral blood is a biological marker for the prognosis of MPM.