| 220例稽留流产者绒毛组织细胞遗传学分析 |
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| 引用本文： | 古艳,;谢建生,;罗福薇,;耿茜,;张华坤,;沈辉宁,;赵坤,;刘庆芝.220例稽留流产者绒毛组织细胞遗传学分析[J].中国优生与遗传杂志,2009(12):38-39. |
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| 作者姓名： | 古艳 ;谢建生 ;罗福薇 ;耿茜 ;张华坤 ;沈辉宁 ;赵坤 ;刘庆芝 |
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| 作者单位： | [1]广州医学院2007级研究生; [2]深圳市妇幼保健院产前诊断中心,518048; [3]深圳市妇幼保健院妇科,518048; |
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| 摘 要： | 目的通过绒毛细胞遗传学分析了解稽留流产患者的病因。方法无菌条件下取220例稽留流产患者胚胎绒毛,采用细胞培养法制备染色体进行G显带分析。结果220例稽留流产患者绒毛细胞培养成功212例（96.36%）,收获染色体207例,成功率97.64%（207/212）,检出染色体异常115例（55.56%）。异常核型中三体72例（62.61%）,性染色体单体16例（13.91%）,多倍体14例（12.17%）,嵌合体10例（8.70%）,结构异常3例（2.61%）。结论胚胎染色体数目异常是稽留流产患者的重要病因,进行绒毛细胞遗传学分析具有重要临床意义。
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| 关 键 词： | 稽留流产 绒毛细胞 染色体分析 |
Chromosome karyotyping of 220 cases of early spontaneous abortion |
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| Affiliation: | GU Yan , XIE Jian - sheng, LUO Fu - wei, GENG Qian, ZHANG Hua - kun, SHEN Hui - ning, ZHAO Kun, LIU Qing - zhi ( 1. Graduate School of Guangzhou Medical College, Guangzhou, Guangdong, China; 2. Central for Prenatal Diagnosis, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong, 518048, China; 3. Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong , 518048, China) |
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| Abstract: | Objective ： To investigate cause of missed abortion. Methods ： Choronic villi from 220 cases of missed abortion were sampled. Tissue culture and karyotype analysis was performed on these samples. Results： The successful cell culture rate was 96. 36% （212/220）. There were 207 （97.64%） cases succeeded in karyotype analysis and 115 cases （55.56 % ） with chromo- some abnormality among 207 cases. Abnormal karyotypes included 72 cases of trisomy, 16 cases of monosomy X, 14 cases of polyploid, 10 cases of chimera and 3 structural abnormity. Conclusion： Chromosome abnormalities was the most important reason in missed abortion, and karyotype analysis of chorionic villus has important clinical significance. |
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| Keywords: | Missed abortion Chorionic villus Karyotype analysis |
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