Radiochemical and biological characterization of 99mTc-oxiracetam as a model for brain imaging |
| |
Authors: | M. H. Sanad E. A. Marzook O. A. El-Kawy |
| |
Affiliation: | 1.Labeled Compounds Department, Hot Laboratories Center,Atomic Energy Authority,Cairo,Egypt;2.Biological Application Department, Nuclear Research Center,Atomic Energy Authority,Cairo,Egypt |
| |
Abstract: | 99mTc-oxiracetam was prepared. It can be used as a radiotracer for brain imaging. Under the optimum conditions (0.5 mg of oxiracetam, 50 μg of SnCl2·2H2O, pH 7, room temperature, 30 min), the radio-chemical yield determined by chromatographic methods reached 96%. Biodistribution studies with mice showed that the brain uptake of the complex was 5.1% injected dose per gram (% ID/g) at 5 min post injection. In this parameter, the complex surpasses the commercially available 99mTc-ECD (4.7% ID/g) and 99mTc-HMPAO (2.25% ID/g). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|