| 不同分割剂量放疗联合唑来膦酸治疗骨转移癌的临床研究 |
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| 引用本文： | 石永刚. 不同分割剂量放疗联合唑来膦酸治疗骨转移癌的临床研究[J]. 中国现代医生, 2008, 46(18): 9-11 |
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| 作者姓名： | 石永刚 |
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| 作者单位： | 郑州大学第一附属医院放疗科,郑州,450052 |
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| 摘 要： | 目的探讨不同分割剂量放疗联合唑来膦酸治疗骨转移癌的疗效。方法将110例骨转移癌患者随机分为3组。3组均静脉点滴唑来膦酸4mg。A组40例采用低分割照射，DT30Gy／10次／3周；B组37例采用常规分割，DT40Gy／20次，4周；C组33例不照射。结果（1）治疗结束时疼痛缓解总有效率为A组90．0％，B组86．5％，C组66．7％（A组与C组X^2=6．03，P〈0．05，B组与C组X^2=3．80，P〈0．05；A组与B组X^2=0．02，P〉0．05）；（2）KPS评分变化为A组82．5％，B组70.3％，C组51．5％（A组与C组X^2=8．04，P〈0．05；B组与C组X^2=4.43，P〈0．05；A组与B组X^2=0．54，P〉0．05）；（3）骨转移灶修复情况A组84．3％，B组76．9％，C组57．7％（A组与C组X^2=10．69，P〈0．05；B组与C组X^2=4．94，P〈0．05；A组与B组X^=1．17，P〉0．05）。结论唑来膦酸联合放疗治疗骨转移癌疗效优于单纯唑来膦酸，但是低分割照射治疗周期短、费用低。
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| 关 键 词： | 放射疗法 唑来膦酸 骨转移癌 |
Clinical Study on Different Fraction Radiotherapy Combined with Zoledronic Acid in the Treatment of Cancer Patients with Bone Metastasis |
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| SHI Yonggang. Clinical Study on Different Fraction Radiotherapy Combined with Zoledronic Acid in the Treatment of Cancer Patients with Bone Metastasis[J]. , 2008, 46(18): 9-11 |
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| Authors: | SHI Yonggang |
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| Affiliation: | SHI Yonggang Department of Radiation Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Objective To evaluate the efficacy of different fraction radiotherapy combined with zoledronic acid for bone metastatic cancer.Methods 110 cases with bone metastatic cancer were randomized into 3 groups.All patients were treated with zoledronic acid,4 mg intravenously.The group A(40 cases) had received hypofraction:DT 30 Gy ten times for three weeks;the group B(37 cases) received conventional fraction:DT 40 Gy,twenty times for four weeks the group C(33 cases) no radiotherapy.Results(1)The total effective ra... |
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| Keywords: | Radiotherapy Zoledronic acid Bone metastatic cancer |
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