| 基于网络药理学和多中心临床数据的清肺承气汤治疗腹腔感染所致急性呼吸窘迫综合征的作用机制研究 |
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| 引用本文： | 王馨培,王子玉,傅强,杜超,巩传勇,王兵. 基于网络药理学和多中心临床数据的清肺承气汤治疗腹腔感染所致急性呼吸窘迫综合征的作用机制研究[J]. 中草药, 2021, 52(2): 437-446 |
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| 作者姓名： | 王馨培 王子玉 傅强 杜超 巩传勇 王兵 |
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| 作者单位： | 天津医科大学研究生院, 天津 300070;湖北省中西医结合医院 重症医学科, 湖北 武汉 430015;天津医科大学研究生院, 天津 300070;天津市第四中心医院 重症医学科, 天津 300140;天津中医药大学第一附属医院 急症部, 天津 300193;天津市南开医院 重症医学科, 天津 300102;天津市第一中心医院 重症医学科, 天津 300190 |
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| 基金项目： | 天津市卫生行业重点攻关项目（15KG121） |
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| 摘 要： | 目的 采用网络药理学和多中心临床数据探讨清肺承气汤治疗腹腔感染所致急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的作用机制.方法 通过中药系统药理学分析平台(Traditional Chinese Medicine Systems Pharmacology Dat...
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| 关 键 词： | 清肺承气汤 腹腔感染 急性呼吸窘迫综合征 网络药理学 槲皮素 木犀草素 白细胞介素 凋亡 |
| 收稿时间： | 2020-06-06 |
Mechanism of Qingfei Chengqi Decoction on acute respiratory distress syndrome caused by abdominal infection based on network pharmacology and multi-center clinical data |
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| WANG Xin-pei,WANG Zi-yu,FU Qiang,DU Chao,GONG Chuan-yong,WANG Bing. Mechanism of Qingfei Chengqi Decoction on acute respiratory distress syndrome caused by abdominal infection based on network pharmacology and multi-center clinical data[J]. Chinese Traditional and Herbal Drugs, 2021, 52(2): 437-446 |
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| Authors: | WANG Xin-pei WANG Zi-yu FU Qiang DU Chao GONG Chuan-yong WANG Bing |
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| Affiliation: | Graduate School, Tianjin Medical University, Tianjin 300070, China;Department of Critical Medicine, Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan 430015, China;Graduate School, Tianjin Medical University, Tianjin 300070, China;Department of Critical Medicine, Tianjin Fourth Central Hospital, Tianjin 300140, China;Emergency Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Department of Critical Medicine, Tianjin Nankai Hospital, Tianjin 300102, China; Department of Critical Medicine, Tianjin First Central Hospital, Tianjin 300190, China |
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| Abstract: | Objective To elucidate the underlying molecular mechanism of Qingfei Chengqi Decoction(清肺承气汤)in treatment of patients with acute respiratory distress syndrome(ARDS)caused by abdominal infection using network pharmacology and multi-center clinical data.Methods Through the database of Chinese Medicine System Pharmacology Analysis Platform(TCMSP),the chemical constituents and targets of Qingfei Chengqi Decoction was retrieved.Cytoscape 3.7.1 software was used to establish a“compound-target”network,a predicted protein-protein interaction(PPI)network between predicted targets,and a KEGG enrichment analysis of predicted targets.A total of 27 patients with ARDS due to celiac infection were selected from three hospitals and were randomly divided into Qingfei Chengqi Decoction group(14 cases)and control group(13 cases).Alveolar lavage fluid was taken 3 d before and after treatment;Levels of IL-4,IL-6,IL-10 were detected by microsphere detection;Alveolar macrophage apoptosis was analyzed by flow cytometry.Results A total of 78 active compounds and 63 potential targets of Qingfei Chengqi Decoction were screened.From“compound-target”network and PPI network,targets ranked the top were PPARγ,Bcl-2,IL-6,IL-10 and INFG;Compounds were quercetin and luteolin.Inflammatory pathways ranked higher in KEGG pathway analysis were NF-κB,TNF signaling pathway,IL-17 pathway and T cell receptor pathway.Compared with control group,level of IL-6 was significantly increased(P<0.05),level of IL-10 was significantly decreased(P<0.05),and apoptotic area of alveolar macrophages was significantly decreased(P<0.001)in Qingfei Chengqi Decoction group.Conclusion Compounds in Qingfei Chengqi Decoction could regulate multiple signal pathways through targets such as IL-6,Bcl-2,IL-10,and CXCL2 to regulate the secretion of IL-4,IL-6,IL-10 and cell apoptosis to treat ARDS. |
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| Keywords: | Qingfei Chengqi Decoction abdominal infection acute respiratory distress syndrome network pharmacology quercetin luteolin interleukin apoptosis |
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