| 1，5－二芳基－8，15－二氧杂二螺－［5，2，5，2］－十六烷－3，7，16－三酮的合成 |
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| 引用本文： | 陈洪超,简锡贤,刘志昌.1，5－二芳基－8，15－二氧杂二螺－［5，2，5，2］－十六烷－3，7，16－三酮的合成[J].华西药学杂志,1995(3). |
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| 作者姓名： | 陈洪超 简锡贤 刘志昌 |
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| 作者单位： | 华西医科大学药学院，乐山师范专科学校 |
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| 摘 要： | 由取代苯甲醛、丙酮、丙二酸、环己酮为原料，合成１，５－二芳基－１．４．戊二烯－３－ｘ酮和１，５－二氧杂螺－［５，５］－十一烷－２，４－二酮，然后在ＰＥＧ和ＫＯＨ存在下，乙醇作溶剂，制备了七个新的二螺环化合物，并对反应条件进行了探讨。七个新化合物对菌类有明显的抑制作用。
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| 关 键 词： | Michael反应，二螺环化合物，PEG |
SYNTHESIS OF 1,5-BISARYL-8,15-DIOXA-DISPRIO-[5,2,5,2]-HEXADEANE-3,7,16-TRIONE |
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| Chen Hongchao,Jian Xixian.SYNTHESIS OF 1,5-BISARYL-8,15-DIOXA-DISPRIO-[5,2,5,2]-HEXADEANE-3,7,16-TRIONE[J].West China Journal of Pharmaceutical Sciences,1995(3). |
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| Authors: | Chen Hongchao Jian Xixian |
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| Abstract: | BisAryl-1,4-pentadien-3-one and 1,5-dioxyasprio-5,5]-undecane-2,4-dione were synthesized by substitated benzaldehyde,acetone,propandioic acid and cyclohexanone as the raw materials.Then, in the prensence of PEG and KOH in ethanol as solvent, seven new dispriocyclic compounds were prepared. Reaction conditions were discussed. |
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| Keywords: | Michael condensation PEG Dispriocyclic compound |
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