miR-138生物学功能研究进展*

microRNAs(miRNAs)是真核生物体内高度保守的非编码小分子RNA,具有多种生物学功能,参与疾病发生和发展、细胞增殖和分化等多种病理及生理过程的调控。miR-138作为一种肿瘤抑制因子已在肿瘤发生与治疗中被广泛研究和应用,同时在心血管及神经系统疾病、成骨分化、脂肪生成及卵巢功能维持等生命过程中具有调控作用。在总结分析miR-138相关功能最新研究进展的基础上,对miR-138的潜在研究方向进行了分析、讨论和展望,旨在为进一步深入探明miR-138的生物学功能提供参考和理论依据。

Research Progress on Biological Functions of miR-138

microRNAs(miRNAs)are highly conserved non-coding small RNA in eukaryotes. They have many biological functions and can participate in the regulation of disease, cell proliferation and differentiation and other biological process. miR-138 as a tumor suppressor has been widely studied in tumorigenesis and therapy and also plays a regulatory role in cardiovascular and neurological disorder processes, osteogenic differentiation, adipogenesis and ovarian function maintenance. In this paper, prospects for future research direction of miR-138 are analyzed and discussed on the basis of summarizing and analyzing the latest research progress of miR-138 related functions, aiming to provide reference and theoretical basis for exploring miR-138 biological functions in the future.