Pharmacokinetics of oral salbutamol controlled-release in Asian patients with asthma |
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Authors: | W. C. Tan H. S. Lee |
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Affiliation: | (1) Department of Medicine, National University of Singapore, Singapore;(2) Department of Pharmacology, National University of Singapore, Singapore |
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Abstract: | Summary Using a double blind, double dummy crossover design, single dose and steady state pharmacokinetics of oral controlled release (SCR) salbutamol 4 mg and 8 mg tablets b. d. has been studied in 8 Asian patients.Plasma salbutamol was measured over 12 h. In 8 patients the single dose mean Cmax was 4.2 ng·ml–1 and 7.7 ng·ml–1 after 4 and 8 mg, respectively. In 5 patients the steady state mean Cmax, Cmin and tmax were 8.1 ng·ml–1 and 4.7 ng·ml–1 and 6 h for the 4 mg tablets and 14.1 ng·ml–1 and 7.1 ng·ml–1 and 4 h for the 8 mg tablets.It is concluded that both doses of SCR show features of controlled release and that they produced a relatively constant plasma level of salbutamol in Asian patients. |
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Keywords: | Asthma Salbutamol Asians pharmacokinetics |
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