| 新型两亲性N-辛基-N-PEG化壳聚糖衍生物的合成与表征 |
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| 引用本文： | 张灿, 丁娅, 平其能. 新型两亲性N-辛基-N-PEG化壳聚糖衍生物的合成与表征[J]. 中国药科大学学报, 2005, 36(3): 201-204. |
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| 作者姓名： | 张灿 丁娅 平其能 |
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| 作者单位： | 中国药科大学药学院,南京,210009 |
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| 基金项目： | 国家自然科学基金，教育部科学技术基金，国家重大科技专项基金 |
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| 摘 要： | 目的:制备新型的两亲性N辛基NPEG化壳聚糖衍生物。方法:以天然聚合物壳聚糖为原料,其2-NH2与辛醛形成Schiff′s碱,用KBH4还原得到N辛基壳聚糖,然后在其剩余2-NH2与MeOPEG-CHO反应,再用KBH4还原制备了N-辛基N-PEG化壳聚糖衍生物,结构经FTIR、13CNMR、1HNMR得到了表征。用DSC实验对其物理性质进行了分析。结果与结论:制得了新型的辛基、PEG取代度分别为36,64%的两亲性N辛基NPEG化壳聚糖衍生物,有望作为难溶性药物增溶的载体。
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| 关 键 词： | 壳聚糖 两亲性 聚合物胶束 合成 |
| 文章编号： | 1000-5048(2005)03-0201-4 |
| 修稿时间： | 2004-09-06 |
Synthesis and Characterization of a Novel Amphiphilic N- octyl- N- pegylated Chitosan Derivative |
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| Zhang Can,DING Y,PING Qi-Neng. Synthesis and Characterization of a Novel Amphiphilic N- octyl- N- pegylated Chitosan Derivative[J]. Journal of China Pharmaceutical University, 2005, 36(3): 201-204 |
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| Authors: | Zhang Can DING Y PING Qi-Neng |
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| Abstract: | AIM:To prepare and characterize a novel amphiphilic N-octyl-N-pegylated chitosan derivative.METHODS:Octyl and PEG group were introduced into the amino group of chitosan;amphiphilicN-octyl-N-pegylated chitosan was synthesized.The chemical structure of the modified chitosan was characterized by elemental analysis,FTIR,()~(1)H NMR and ()~(13)C NMR.Some physical properties were measured by DSC.RERULTS and CONCLUSION:A novel amphiphilicN-octyl-N-pegylated chitosan derivative was synthesized with the degree of octyl and PEG substitution 36% and 64%,respectively.It may be used as a hydrophobic drug carrier. |
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| Keywords: | Chitosan Amphiphilic Polymeric micelle Synthesis |
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