聚己内酯/羟基磷灰石晶须复合多孔支架的研究

采用溶液浇铸法,以二氯甲烷作为溶剂,制备了聚己内酯/羟基磷灰石晶须(PCL/HAw)复合多孔支架,并进行了正交试验,综合分析了不同配方量的PCL和HAw对材料机械性能的影响。结果表明,可通过控制PCL的量来控制支架的力学性能,通过加入HAw提高支架的亲水性能,支架的接触角实验显示其接触角为81°;PCL的结晶度会随着HAw含量的增加而增强,复合多孔支架的抗拉强度为1.43M~9.21MPa,并在PCL与HAw的质量比为100∶3时达到最大;细胞毒性实验显示,PCL/HAw复合多孔支架细胞毒性为0,满足生物材料使用要求。

Fabrication and property of PCL/HAw composite porous scaffold

Polycaprolactone(PCL)/hydroxyapatite whisker(HAw)composite porous scaffolds were prepared by solution casting method with dichloromethane as solvent.The orthogonal test was conducted to compare composites with the different formulas of PCL and HAw.The results shown that the mechanical properties of the scaffolds were controlled by the amount of PCL.The hydrophilicity of the scaffolds could be improved by adding HAw.The composites shown that the contact angle was 81°,which was hydrophilic.The crystallinity of PCL increased with the increasing of HAw.The tensile strength of the scaffolds was 1.43~9.21 MPa,and reached to the maximum when the mass ratio of PCL to HAw was 100∶3.The cytotoxicity experiment showed that the cytotoxicity of the scaffolds was 0,which could meet the requirements for the use of biological materials.