Discovery of novel,orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists |
| |
| Authors: | Pradip K Sasmal Sanjita Sasmal P Tirumala Rao B Venkatesham M Roshaiah Chandrasekhar Abbineni Ish Khanna Vikram P Jadhav J Suresh Rashmi Talwar Syed Muzeeb Jean-Marie Receveur Thomas M Frimurer Øystein Rist Lisbeth Elster Thomas Högberg |
| |
| Affiliation: | 1. Discovery Research, Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500 049, India;2. 7TM Pharma A/S, Fremtidsvej 3, DK-2970 Hørsholm, Denmark |
| |
| Abstract: | Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
