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Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study |
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| Authors: | Peter D Ahiawodzi Richard A Kerber Kira C Taylor Frank D Groves Elizabeth O'Brien Joachim H Ix |
| Affiliation: | 1. Department of Public Health, Campbell University College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC, United States;2. Department of Epidemiology &3. Population Health, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, United States;4. Department of Medicine and Family and Preventive Medicine, University of California San Diego, La Jolla, United States |
| Abstract: | Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) – a source of oxidative stress – and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR?=?1.63, 95%CI?=?1.03–2.58, p?=?0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB |
| Keywords: | Carboxymethyl-lysine advanced glycation end-product sleep-disordered breathing oxidative stress Apnea–Hypopnea Index |
