Decreased bone formation in osteoporotic patients compared with age-matched controls |
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Authors: | M Garcia Carasco M C de Vernejoul Y Sterkers C Morieux D Kuntz L Miravet |
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Affiliation: | (1) INSERM U18, Clinique de rhumatologie Hopital Lariboisière, 6 rue Guy Patin, 75010 Paris, France;(2) Service d'Orthopédie Hopital Henri Mondor, Cretail, France |
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Abstract: | Summary In order to study trabecular bone remodeling in postmenopausal osteoporosis we compared bone biopsies of 44 osteoporotic women
aged 50–70 to those of 23 nonosteoporotic women, matched for age, who had a bone biopsy during anesthesia for knee arthritis.
Trabecular bone volume, mean wall thickness, osteoblastic surfaces, labeled surfaces, and bone formation rate were decreased
in osteoporotic women compared with control women. The osteoclast number and the osteoclastic surfaces were the same in the
two groups. The normal distribution of the histomorphometric static parameters in osteoporotic patients did not allow the
separation of subgroups. These data indicate that decreased bone formations is a major contributing factor leading to trabecular
bone loss in postmenopausal osteoporosis. |
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Keywords: | Osteoporosis Bone formation Histomorphometry Osteoblasts |
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