多囊卵巢综合征伴不孕子宫内膜的研究进展

多囊卵巢综合征（PCOS）是育龄妇女无排卵性不孕的主要原因之一.其主要内分泌特征为高雄激素血症、高胰岛素血症和胰岛素抵抗、LH水平和LH/FSH比值升高.目前的研究发现,即使对PCOS患者进行促排卵治疗,妊娠率仍相当低.因此,不孕的因素除了慢性不排卵外,还与子宫内膜局部环境的改变有关,其不正常的内分泌状况导致的不良子宫内膜环境对胚胎发育的影响引起研究者的普遍关注.目前,子宫内膜胰岛素受体表达已成为研究的热点.

The advance in the endometrial study on PCOS with infertility

Polycystic ovary syndrome （PCOS） is one of the principal causes of anovulatory infertility in reproductive age. The main endocrine characteristics of PCOS include hyperandrogenism, hyperinsulinemia, insulin resistance,the increasing level of luteinizing homone （LH）, the increasing ratio of LH and follicle-stimulating homone （FSH）. Recently research show that even the result of induced ovulation is satisfied, the prenant ratio is still low. Besides anovulation, there is another reason such as local endometrial factors that is related to infertility in PCOS. Abnormal endometrial environment resulted from endocrine disorder is a great disadvantage to embryo. Currently, the research for expression of insulin receptor protein in endometrium is a hot topic.