清热逐瘀汤对慢性前列腺炎相关性功能障碍患者NIH-CPSI及前列腺液中WBC和SPL计数的影响

目的:探讨清热逐瘀汤对慢性前列腺炎(chronic prostatitis,CP)相关性功能障碍(erectile dysfunction,ED)、前列腺炎症状及前列腺液中白细胞(white blood cell,WBC)和软磷脂小体(small particle of lecithin,SPL)计数的影响。方法:选取CP合并ED患者80例,按照随机数字表法分成试验组与对照组,每组各40例。试验组口服中药清热逐瘀汤(每次200 mL,每日两次)并联合枸橼酸西地那非(25 mg,睡前1 h口服),对照组口服前列欣胶囊(每次6粒,每日3次)并联合枸橼酸西地那非(25 mg,睡前1 h口服),疗程为4周。比较治疗前后患者美国国立卫生研究院慢性前列腺炎症状评分(National Institutes of Health-chronic prostatitis score,NIH-CPSI)、中医证候积分、前列腺液检查指标(WBC、SPL计数)、ED国际勃起功能评分、勃起硬度级数及两组患者临床疗效。结果:试验组治疗4周及12周后NIH-CPSI分别为(9.68±1.68)分和(10.12±1.78)分,对照组分别为(14.58±2.44)分和(19.58±3.14)分,两组比较,差异均有统计学意义(P<0.05);试验组治疗12周后与治疗前比较,差异有统计学意义(P<0.05)。两组中医证候积分治疗4周及12周后比较,差异有统计学意义(P<0.05)。两组治疗4周、12周后前列腺液中WBC和SPL计数比较,差异均有统计学意义(P<0.05)。试验组治疗4周及12周后国际勃起功能评分为(19.02±3.18)分和(16.32±2.36)分,对照组为(15.88±3.28)分和(12.48±2.17)分,组间比较,差异均有统计学意义(P<0.05);试验组治疗12周后与治疗前比较,差异有统计学意义(P<0.05)。试验组和对照组患者临床有效率分别为95.0%、82.5%,两组比较,差异有统计学意义(P<0.05)。结论:清热逐瘀汤治疗慢性前列腺炎相关性功能障碍临床疗效确切,可显著降低NIH-CPSI、中医证候评分、WBC计数,提高SPL计数、国际勃起功能评分。

Effect of Qingre Zhuyu Method on NIH-CPSI Score and WBC and SPL Counts in Prostatic Fluid in Patients with Chronic Prostatitis Related Erectile Dysfunction

Objective:To explore the effect of Qingre Zhuyu Method(Qingrezhuyu Decoction+Low-dose sildenafil)on Chronic Prostatitis(CP)related erectile dysfunction(ED),prostatitis Symptoms and white blood cell(WBC)and small particle of lecithin(SPL)counts in prostatic fluid.Methods:80 patients with CP related ED were selected and divided into an experimental group and a control group according to the random number table method,40 cases in each group;the experimental group took Qingrezhuyu Decoction(200 mL at a time,b.i.d.)and combined with citrate Denafil(25 mg at a time,1 hour before bedtime),control group orally administered Qianliexin capsules(6 capsules at a time,three times a day)in combination with sildenafil citrate(25 mg,taken orally 1 hour before bedtime)for 4 weeks;Compare CP NIH-CPS scores before and after treatment,integral of TCM Syndrome,prostate fluid examination indicators(leukocytes,lecithin body count)and ED IIEF-5 scores to observe the clinical efficacy of the two groups.Results:The NIH-CPSI scores were(9.68±1.68)and(10.12±1.78)points in the experimental group after 4 weeks and 12 weeks of treatment,and(14.58±2.44)points and(19.58±3.14)points in the control group,respectively.In comparison,the differences were statistically significant(P<0.05);after 12 weeks of treatment in the test group,the differences were statistically significant(P<0.05).Comparing the two groups of TCM syndrome scores after 4 weeks and 12 weeks of treatment,the difference was statistically significant(P<0.05).The WBC and SPL counts in the prostate fluid in the test group after 4 weeks of treatment were:(24.18±4.68)HP-1 and(30.86±8.38)HP-1,respectively,and the control group were:(32.16±5.72)HP-1 and(24.42±4.16)HP-1,the differences between groups were statistically significant(P<0.05).The international erectile function scores of the test group were(19.02±3.18)and(16.32±2.36)points after 4 weeks and 12 weeks of treatment,and the control group were(15.88±3.28)points and(12.48±2.17)points.Comparisons between groups,differences All were statistically significant(P<0.05);the difference between the experimental group after 12 weeks of treatment and before treatment was statistically significant(P<0.05).The clinical effective rates of the experimental group and the control group were 95.0%and 82.5%,respectively.The difference between the two groups was statistically significant(P<0.05).Conclusion:Qianlie Zhuyu method has a definite clinical effect in treating chronic prostatitis-related dysfunction,which can significantly reduce NIH-CPSI,TCM syndrome score,WBC count,and increase SPL count and international erectile function score.