| 聚合酶链反应检测冠心病患者外周血人巨细胞病毒 |
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| 引用本文： | 冯久贤,包国良,江晓丰,王恩来,张雷,倪幼芳.聚合酶链反应检测冠心病患者外周血人巨细胞病毒[J].临床心血管病杂志,1998,14(2):1. |
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| 作者姓名： | 冯久贤 包国良 江晓丰 王恩来 张雷 倪幼芳 |
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| 作者单位： | 上海市胸科医院,200030 |
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| 摘 要： | 目的：探讨人类巨细胞病毒（HCMV）与动脉粥样硬化（AS）的关系及外周血检测的意义。方法：应用聚合酶链反应特异扩增HCMV早期抗原区。结果：冠心病组64例外周血阳性43例（67.2％）；健康对照组30例中阳性3例（10.0％），两组比较，差异有显著意义（P＜0.05）。结论：HCMV可能是AS的一种致病因子，并可从外周血中检出。
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| 关 键 词： | 聚合酶链反应 巨细胞病毒 动脉粥样硬化 冠心病 |
The detection of cytomegalovirus in the peripheral blood cells of patients with coronary heart disease |
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| Feng Jiuxian, Bao Guoliang, Jiang Xiaofeng, et al.The detection of cytomegalovirus in the peripheral blood cells of patients with coronary heart disease[J].Journal of Clinical Cardiology,1998,14(2):1. |
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| Authors: | Feng Jiuxian Bao Guoliang Jiang Xiaofeng |
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| Abstract: | Objective:To investigate the relationship between coronary heart disease and cytomegalovirus (CMV) infection. Methods:Major immediate-early antigen region of CMV was distingiushed by using ploymerase chain reaction (PCR). Results:In 64 patients with coronary heart disease,43 cases (67.1 %) were considered as positive for CMV infection. In comparasion,positive band was detected in only 10% (3/30 cases) of healthy objectives. This difference in CMV infection between two groups was statistically significant (P <0.05). Conclusion :CMV infection may be an important factor in the pathogenesis of atherosclerosis and this virus can be detected in the peripheral blood cells. |
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| Keywords: | Polymerase chain reaction Cytomegalovirus Atherosclerosis Coronary heart disease |
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