| 人主动脉硫酸乙酰肝素蛋白聚糖对胎儿主动脉平滑肌细胞c-fos和c-myc基因表达的影响 |
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| 引用本文： | 刘俊明,丛祥凤,张春玲,张英珊.人主动脉硫酸乙酰肝素蛋白聚糖对胎儿主动脉平滑肌细胞c-fos和c-myc基因表达的影响[J].中国动脉硬化杂志,1996,4(2):112-114. |
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| 作者姓名： | 刘俊明 丛祥凤 张春玲 张英珊 |
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| 作者单位： | 中国北京协和医科大学中国医学科学院,北京心血管病研究所阜外心血管病医院，北京 100037 |
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| 摘 要： | 本室以往的研究发现硫酸乙酰肝素蛋白聚糖对培养的胎儿主动脉平滑肌细胞的增殖有明显的抑制作用。本实验采用Ｎｏｒｔｈｅｒｎｂｌｏｔ方法观察硫酸乙酰肝素蛋白聚糖对胎儿主动脉平滑肌细胞的ｃ－ｆｏｓ，ｃ－ｍｙｃ原癌基因的表达的影响，发现前者能抑制后者的表达。因此硫酸乙酰肝素蛋白聚糖抑制平滑肌细胞增殖的途径之一可能为抑制原癌基因的表达。
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| 关 键 词： | 硫酸乙酰肝素 蛋白聚糖 原癌基因 动脉粥样硬化 |
| 收稿时间： | 1996/5/12 0:00:00 |
| 修稿时间： | 1996/6/19 0:00:00 |
The Effect Of Human Aortic Heparan Sulfate Proteoglycan on the Expression of c-fos and c-myc Gene in the Cultured Fetal Aortic Smooth Muscle Cells |
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| Affiliation: | Prevention and Control Center of Metabolic Disease,Tianjin Medical University, Tianjin 300070,China |
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| Abstract: | Our laboratory have found that human aortic heparan sulfate proteoglycan(HSPG) can suppress the proliferation of cultured fetal aortic smooth muscle cells(hASMC).In this study Norther blot was used to invetigate the effect of HSPG on the expression of c-fos and c-myc proto-oncogene in hASMC. The results showed that former can suppress both c-fos and c-myc gene. It is concluded that suppression of protooncogene expression may be one of the causes that HSPG suppresses smooth muscle cell proliferation. |
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| Keywords: | :Heparan sulfate proteoglycan Smooth muscle cell Proto-oncogene |
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