清开灵注射液辅助治疗小儿肺炎有效性和安全性的 Meta 分析

[摘要] 目的:系统评价清开灵注射液辅助治疗小儿肺炎的有效性和安全性。 方法:计算机检索Web of science、Embase、Cochrane Library、Pubmed、CNKI、万方数据库、VIP、中国生物医学数据库(CBM)电子数据库,纳入清开灵注射液辅助治疗小儿肺 炎的随机对照试验(RCT),由两名研究者独立选择试验和评价质量,提取有效数据,应用 RevMan 5.3.3 软件进行 Meta 分析。 结果:共纳入RCT 22 项,病例共计 2 400 例。 Meta 分析显示,在常规治疗基础上辅以清开灵注射液治疗小儿肺炎,在总有效率、 体温恢复正常时间、咳嗽消失时间、肺部啰音消失时间、呼吸频率改善时间、呕吐改善时间等方面均优于单纯常规治疗( P<0.05),但不会缩短住院时间(P>0.05)。 结论:现有文献支持清开灵注射液辅助治疗小儿肺炎,但由于现有支持文献质量不高, 仍有待更多高质量、大样本、多中心的RCT 加以验证。

Meta-Analysis on Effectiveness and Safety of Qingkailing Injection in Treatment of Pediatric Pneumonia

[Abstract] Objective: To systemically review the effectiveness and safety of Qingkailing injection in the treatment of pediatricpneumonia. Methods: The databases of Web of science, Embase, Cochrane Libray, Pubmed, CNKI, Wan Fang, VIP and CBM wereretrieved for collecting the randomized controlled trials ( RCT) about the treatment of pediatric pneumonia with Qingkailing injection.The selection and data collection were conducted independently by two investigators, and the included studies were assessed. All the Meta-analyses were performed by Review Manager 5.3.3. Results: Twenty-two RCTs and 2,400 cases were included. From the resultsof Meta-analysis, the effectiveness of Qingkailing group was superior to the control group in the overall efficiency, defervescence time,cough disappeared time, rales disappeared time, breathing rate improvement time, vomiting improvement time ( P < 0.05), but thelength of hospital stay was not reduced by the addition of Qingkailing injection (P>0.05). Conclusion: The existing literature supportsthe treatment of pediatric pneumonia by Qingkailing injection. However, due to the low quality of supporting documents, more highquality, large samples and multi-center RCTs are still needed to be verified.