脂肪来源干细胞治疗心肌梗死的现状及策略

急性心肌梗死是最常见的心血管疾病之一，由于冠状动脉供血不全导致心肌细胞大量坏死、生存微环境恶化，近期可发生心肌细胞机械-电生理功能紊乱，远期可导致心力衰竭。目前的临床治疗方法虽能在一定程度上改善心功能，减轻心室重塑，但由于心肌细胞再生能力有限，心脏功能难以完全恢复正常。近年来，脂肪来源干细胞移植治疗急性心肌梗死受到广泛关注，但由于移植后细胞的存留和存活率普遍较低，总体治疗效果并不理想。本文对目前脂肪来源干细胞治疗急性心肌梗死的现况及提高其疗效的途径和方法作一综述。

Current situation and strategies in the treatment of myocardial infarction by adipose-derived stem cells

Acute myocardial infarction is one of the most common cardiovascular diseases. Due to the insufficiency of coronary artery blood supply, cardiomyocyte death occurs and microenvironment deteriorates, followed by mechanical-electrophysiological dysfunction in early stage and heart failure in long term. At present, treatment of myocardial infarction can improve cardiac function and reduce ventricular remodeling in a certain extent. However, it is difficult to restore cardiac function completely due to the limited regenerative capacity of cardiomyocytes. In recent years, transplantation of adipose-derived stem cells has attracted extensive attention. However, the cell survival and engraftment rate after transplantation are generally low and the therapeutic effect is not ideal. This article reviews the current situation of adipose-derived stem cells in the treatment of acute myocardial infarction and the ways and methods that may improve its therapeutic effect.