| 固有CD4+CD25+调节性T细胞与其在移植耐受上的进展 |
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| 引用本文： | 蔡永君,孙文佶. 固有CD4+CD25+调节性T细胞与其在移植耐受上的进展[J]. 国际免疫学杂志, 2006, 29(3): 196-200 |
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| 作者姓名： | 蔡永君 孙文佶 |
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| 作者单位： | 310031 杭州,浙江大学免疫学研究所;浙江大学医学院免疫学研究所 |
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| 摘 要： | 固有CD4 CD25 调节性T细胞(naturally occurringCD4 CD25 regulatory T cells,nTreg)是在胸腺发育的功能成熟的T细胞亚群,可通过下调效应性免疫细胞的功能和增殖来抑制或控制机体免疫应答的程度,并维持机体自身免疫耐受。近年来的研究发现,nTreg对外源性抗原(如移植物同种抗原)也能产生特异性的免疫耐受。该文将就近年来nTreg在细胞标记、作用机制及其在移植耐受方面的研究进展进行综述。
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| 关 键 词： | nTreg 细胞标记 作用机制 移植耐受 |
| 文章编号： | 1673-4394(2006)03-0196-04 |
| 收稿时间： | 2005-04-19 |
| 修稿时间： | 2005-04-19 |
Development of natural occurring CD4+CD25+ regulatory T cells and its function in transplantation tolerance |
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| CAI Yong-jun. Development of natural occurring CD4+CD25+ regulatory T cells and its function in transplantation tolerance[J]. International Journal of Immunology, 2006, 29(3): 196-200 |
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| Authors: | CAI Yong-jun |
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| Affiliation: | Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310031, China |
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| Abstract: | Naturally occurring CD4 CD25 regulatory T cells (nTreg) is a functionally distinct and mature subpopulation of T cells developed from thymus.nTreg can suppress or control immune responses and maintain self-tolerance through down-regulating function and proliferation of immune cells.From recent research,we found nTreg can also induce specific immune tolerance to nonself antigens,such as transplant alloantigen.This review will give you some information on the development of nTreg in its molecular markers,tolerance mechanisms,and its function in establishing transplantation tolerance. |
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| Keywords: | nTreg Cell marker Tolerance mechanism Transplantation tolerance |
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