葛根素治疗缺血性脑卒中的临床研究分析

目的 了解目前葛根素治疗缺血性脑卒中临床研究的现状及能否为临床实践提供可靠的依据。方法 通过机检和手检全面收集全世界范围内发表的有关葛根素治疗缺血性脑卒中的研究章，并按临床流行病学标准对纳入的章进行分析。结果纳入随机对照试验(RCT)35篇，有对照未随机分组的试验22篇，无对照的系列病例观察17篇。有全国性诊断标准占74．3％，纳入标准占9．5％，仅4篇为半随机分配，余未描述随机方案。1篇双盲，2篇单盲，随访期均不超过30天。结论 葛根素治疗缺血性脑卒中的临床研究的质量低，还不能满足临床实践的需要。

Analysis of clinical studies on puerarin for ischemic stroke

Objective To investigate the current situation of clinical studies on puerarin for ischemic stroke and the reliability of these evidence. Methods By electronic searching and handsearching ,we collected all the published clinical study reports on puerarin for ischemic stroke and assessed all the included reports according to clinical epidemiologic standard. Results 35 RCTs, 22 non-randomized controlled trials and 17 case serials studies were included and analysed. Conclusions Current quality of clinical studies of puerarin for ischemic stroke is not good enough to provide reliable evidence.