| SARS病毒膜融合抑制剂的鉴定 |
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| 引用本文： | 潘浩,陈永井,周迎会,吴士良. SARS病毒膜融合抑制剂的鉴定[J]. 江苏大学学报(医学版), 2006, 16(3): 200-203,F0005 |
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| 作者姓名： | 潘浩 陈永井 周迎会 吴士良 |
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| 作者单位： | 苏州大学医学院生物化学与分子生物学教研室;苏州大学附属第一医院;苏州大学医学生物技术研究所,江苏,苏州,215123;苏州大学医学院生物化学与分子生物学教研室 |
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| 基金项目： | 江苏省高校自然科学基金 |
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| 摘 要： | 目的：用分子对接技术预测HIV融合抑制剂是否能对SAILS起作用。方法：搜寻HIVsp41融合抑制剂，用DOCK软件分析其与SAILS蛋白的S2结构域HRl三聚体晶体结构的亲和力。结果：预测了23个小分子。ADS-J1、ADS-J2、XTYFormazan等几个小分子得分较高，提示与S2结构域有亲和力。结论：发现抗HIV的融合抑制剂有可能对SARS起作用。
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| 关 键 词： | SARS DOCK 融合抑制剂 S蛋白 |
| 文章编号： | 1671-7783（2006）03-0200-04 |
| 收稿时间： | 2006-05-16 |
| 修稿时间： | 2006-05-16 |
Identifying inhibitors of the SARS coronavirus membrane fusion |
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| PAN Hao,CHEN Yong-jing,ZHOU Ying-hui,WU Shi-liang. Identifying inhibitors of the SARS coronavirus membrane fusion[J]. Journal of Jiangsu University Medicine Edition, 2006, 16(3): 200-203,F0005 |
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| Authors: | PAN Hao CHEN Yong-jing ZHOU Ying-hui WU Shi-liang |
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| Affiliation: | 1. Department of Biochemistry and Molecular Biology, Soochow University; 2. the First Affiliated Hospital of Soochow University; 3. Institute of Medical Biotechnology, Soochow University, Suzhou Jiangsu 215123, China |
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| Abstract: | Objective: We used docking techniques to investigate whether chemical compounds which inhibit HIV membrane fusion have the ability against fusion of SARS-CoV with target cells.Methods: We searched and selected the chemical compounds against HIV membrane fusion from PubChem database.The binding affinities of HIV fusion inhibitors to SARS-CoV central HR1 coiled coil structure were predicated using DOCK version 5.1.1. Results: The ADS-J1,ADS-J2,XTT Formazan have binding affinities for SARS fusion core,because they obtained high score in docking calculations. Conclusion: Existing HIV membrane fusion inhibitors may have the similar inhibiting activities against SARS-CoV |
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| Keywords: | SARS DOCK |
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