| Development of a rat C6 brain tumor model |
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| 作者姓名： | 章翔 吴景文 高大宽 费舟 屈延 荆俊杰 |
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| 作者单位： | Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China;Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China;Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China;Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China;Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China;Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical Uni versity, Xi’an 710032, China |
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| 基金项目： | ThisstudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 39970 75 2 ) |
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| 摘 要： | Objective To establish rat C6 brain- tumor models and find a simple reliable index to judg e tumor volume. Methods C6 cell suspension (10 μl) containing 10 g/L agarose and 1×10［6］ cells was i njected into the right caudate nucleus of the rat brain by a stereotaxic method . After implantation, rats were observed and given MRI scans. Rats were perfus ed with paraformaldehyde trans- aorta at the 10th, 15th, 20th and 25th day and b efore natural death. All brains, lungs, spinal cords and tumors were sectioned and inspected. Tumor- containing samples were prepared histologically by hemato xylin and eosin (HE) stains. Results Fifty implanted rats had 100% yield of intracerebral growth, with distant metast asis of 0% to 4%. Conclusion A rat C6 brain- tumor model was successfully established. Rat survival time is correlated with tumor volume and may be useful as an index of tumor size .
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| 关 键 词： | C6 glioma cell · stereotaxic implanta tion · rat · brain |
Development of a rat C6 brain tumor model |
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| ZHANG Xiang,WU Jingwen,GAO Dakuan,FEI Zhou,QU Yan,JING Junjie.Development of a rat C6 brain tumor model[J].Chinese Medical Journal,2002,115(3):455-457. |
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| Authors: | ZHANG Xiang WU Jingwen GAO Dakuan FEI Zhou QU Yan JING Junjie |
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| Abstract: | |
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| Keywords: | C6 glioma cell stereotaxic implantation rat brain |
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