Formation of apatite nano-needles on novel gel derived SiO2-P2O5-CaO-SrO-Ag2O bioactive glasses |
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| Affiliation: | 1. Key Lab of Eco-Textile, Ministry of Education, Donghua University, North Renmin Road 2999, Shanghai 201620, PR China;2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China;3. Department of Pathophysiology, Wenzhou Medical University, Wenzhou, 325027, PR China;4. Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, 02115, USA;5. Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia;1. College of Materials Science and Engineering, Sichuan University, Chengdu, PR China;2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, PR China;3. Analytical & Testing Center, Sichuan University, Chengdu 610064, PR China;1. Department of Mechanical & Industrial Engineering, Ryerson University, Toronto, ON, Canada;2. Li Ka Shing Knowledge Institute, St. Michael''s Hospital, Toronto, ON, Canada;3. Department of Biomedical Engineering, University Malaya, Kuala Lumpur, Malaysia |
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| Abstract: | A novel SiO2-P2O5-CaO-SrO-Ag2O bioactive glass containing from 0 to 10 mol% Ag2O was produced via the sol-gel method. The influence of silver content on in vitro hydroxyapatite (HA) formation, antibacterial and cell viability properties were investigated. The apatite shape and structure were evaluated by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction analysis (XRD). The results demonstrated that the rate of formation of crystalline HA on SiO2-P2O5-CaO-SrO-Ag2O bioactive glass containing 5% Ag2O (BG-5A) was higher in comparison with other specimens. Formation of apatite nano-needles on the SiO2-P2O5-CaO-SrO-5%Ag2O surface in vitro, after 3 days soaking in SBF solution, demonstrated high bioactivity. The alkaline phosphatase (ALP) and 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay evaluation methods illustrated that the presence of low silver (3% and 5% Ag2O) had stimulating effect on promoting both differentiation and proliferation of G292 osteoblastic cells. Finally, results offer that specimen BG-5A is well candidate for bone tissue application with considerable high antibacterial potential, bioactivity and optimal cell viability. |
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| Keywords: | Sol-gel processes Biocompatibility Bioactivity Antibacterial Nano-needle Hydroxyapatite |
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