伏立康唑注射液治疗血液肿瘤化疗后合并侵袭性肺部真菌感染的临床疗效

目的:分析伏立康唑注射液在血液肿瘤化疗后合并侵袭性肺部真菌感染（IPFI）经验性抗感染治疗的有效性和安全性。方法:回顾性分析2017年7月至2019年7月中国医学科学院肿瘤医院深圳医院合并IPFI的55例血液肿瘤患者应用伏立康唑注射液治疗的临床经验，其中男34例，女21例，中位年龄43.5岁（16～75岁），观察患者应用伏立康唑注射液治疗后的临床疗效和不良反应。结果:本组55例患者诊断为IPFI感染，其中确诊6例、临床诊断24例、拟诊25例，全部患者均有典型的CT影像学表现，使用伏立康唑注射液治疗的中位时间是18.5天（7～56天），应用伏立康唑注射液过程中有12例患者出现一过性幻觉，没有其它药物不良反应。最终全组患者有48例治愈、7例死亡，总有效率为87.3%。结论:伏立康唑注射液治疗IPFI疗效好，不良反应轻微，值得临床进一步应用。

Clinical efficacy of voriconazole injection in the treatment of invasive pulmonary fungal infection after chemotherapy of hematologic tumor

Objective:To analyse the efficacy and safety of voriconazole injection in the treatment of invasive pulmonary fungal infection（IPFI） after hematologic chemotherapy.Methods:We retrospectively analyzed the clinical data of 55 patients with hematologic malignancies and IPFI in Cancer Hospital & Shenzhen Hospital，Chinese Academy of Medical Sciences from July 2017 to July 2019，including 34 males and 21 females，with a median age of 43.5 years（16 to 75 years）.The clinical efficacy and adverse reactions of patients treated with voriconazole injection were observed.Results:In this group，55 patients were diagnosed with IPFI infection，of which 6 cases were confirmed，24 cases were clinically diagnosed and 25 cases were to be diagnosed.All patients had typical CT imaging findings.The median time of using voriconazole injection was 18.5 days（7 to 56 days）.In the process of application of voriconazole injection，12 patients had a transient hallucination without any other adverse drug reactions.In the end，48 cases were cured and 7 cases died.The overall effective rate was 87.3%.Conclusion:Voriconazole injection is an effective and well-tolerated antifungal agent for IPFI in the patients with hematologic malignancies，which is worthy of further clinical application.