| 减肥食品及保健食品中非法添加化学药物酚酞、盐酸西布曲明的探索性检测 |
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| 引用本文： | 吴泽君,刘水平,郭世明. 减肥食品及保健食品中非法添加化学药物酚酞、盐酸西布曲明的探索性检测[J]. 中国药师, 2011, 14(4): 517-520 |
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| 作者姓名： | 吴泽君 刘水平 郭世明 |
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| 作者单位： | 株洲市食品药品检验所 湖南株洲412000 |
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| 摘 要： | 目的:建立减肥食品及保健食品中非法添加化学药物酚酞、盐酸西布曲明的定性、定量检测方法。方法:采用薄层色谱法初筛,高效液相色谱-质谱联用法进行定性鉴别,高效液相色谱法同时进行含量测定。结果:薄层色谱鉴别斑点清晰,重复性好;高效液相色谱-质谱联用鉴别专属性强,灵敏度高;高效液相色谱含量测定方法准确可靠,酚酞、盐酸西布曲明浓度分别在2.9～175.3μg·ml-1（r=0.999 8）和2.7～161.5μg·ml-1（r=0.999 9）范围内与峰面积呈良好的线性关系,平均回收率分别为98.41%（RSD=1.61%）和100.83%（RSD=1.63%）。结论:本方法可有效监测减肥食品及保健食品中非法添加酚酞、盐酸西布曲明。
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| 关 键 词： | 减肥食品 保健食品 酚酞 盐酸西布曲明 薄层色谱 液质联用 高效液相色谱 |
Exploratory Detection of Chemical Drugs Phenolphthalein and Sibutramine Hydrochloride Added Illegally into Slimming Food and Health food |
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| Wu Zejun , Liu Shuiping , Guo Shiming. Exploratory Detection of Chemical Drugs Phenolphthalein and Sibutramine Hydrochloride Added Illegally into Slimming Food and Health food[J]. China Pharmacist, 2011, 14(4): 517-520 |
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| Authors: | Wu Zejun Liu Shuiping Guo Shiming |
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| Affiliation: | Wu Zejun,Liu Shuiping,Guo Shiming(Zhuzhou Institute for Food and Drug Control,Hunan Zhuzhou 412000,China) |
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| Abstract: | Objective:To establish a method for identification and determination of chemical drugs phenolphthalein and sibutramine hydrochloridein added illegally into slimming food and health food.Method:Phenolphthalein and sibutramine hydrochloride in slimming food and health food were identified preliminarily by TLC and identified accurately by HPLC-MS simultaneously,and the contents were determined by HPLC.Result:The spots in TLC were clear and reproducible,and the identification method by HPLC-MS was highly specif... |
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| Keywords: | Slimming food Health food Phenolphthalein Sibutramine hydrochloride TLC LC-MS HPLC |
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