Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. |
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Authors: | Alan Ho Steven F Dowdy |
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Affiliation: | Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, UCSD, 9500 Gilman Drive, La Jolla, California 92093-0686, USA. |
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Abstract: | Progression of resting quiescent G(0) cells into early G(1) and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G(0) to early G(1) transition and metabolism to neoplastic cells. |
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