阿托伐他汀联合抗血小板药治疗对脑血栓临床效果、血小板参数及预后分析

目的探析阿托伐他汀与抗血小板药联合治疗脑血栓的临床果,同时对患者的血小板参数及预后情况展开研究.方法90例脑血栓患者,随机分为参照组和联合组,每组45例.参照组患者采取常规对症治疗,联合组患者在参照组基础上予以阿托伐他汀与抗血小板药物联合治疗.比较两组患临床疗效、治疗前后血小板参数(血小板计数、血小板粘附率以及平均血小板体积)及后遗症、脑血管事件复发情况.结果联合组的总有效率91.1%显著高于参照组的75.6%,差异具有统计学意义(P<0.05).治疗后,两组患者的血小板计数、血小板粘附率以及平均血小板体积水平均低于本组治疗前,且联合组显著低于参照组,差异均具有统计学意义(P<0.05).联合组后遗症发生率6.7%低于参照组的22.2%,差异有统计学意义(P<0.05).联合组脑血管事件复发率13.3%低于参照组的0,差异具有统计学意义(P<0.05).结论对脑血栓患者采取阿托伐他汀与抗血小板药物联合治疗,疗效明显,且可改善患者的血小板参数,减少后遗症发生率,值得在临床上推广与运用.

Clinical effect,platelet parameters and prognosis analysis of atorvastatin combined with antiplatelet drugs on cerebral thrombosis

Objective To discuss and analyze the clinical effect,platelet parameters and prognosis analysis of atorvastatin combined with antiplatelet drugs on cerebral thrombosis.Methods A total of 90 cerebral thrombosis patients were randomly divided into control group and combined group,with 45 cases in each group.The control group received routine symptomatic treatment,and the combined group received atorvastatin combined with antiplatelet drugs on the basis of the control group.The clinical efficacy,platelet parameters(platelet count,platelet adhesion rate and mean platelet volume)before and after treatment and occurrence of sequelae,recurrence of cerebrovascular events were compared between the two groups.Results After treatment,the total effective rate in the combined group was 91.1% significantly higher than 75.6% in the control group,and the difference was statistically significant(P<0.05).After treatment,the platelet count,platelet adhesion rate and mean platelet volume in the two groups were lower than those before treatment,and the combined group was significantly lower than the control group.Their difference was statistically significant(P<0.05).The incidence of sequela in the combined group was 6.7% lower than 22.2% in the control group,and the difference was statistically significant(P<0.05).The recurrence rate of cerebrovascular events in the combined group was 0 lower than 13.3% in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of atorvastatin and antiplatelet drugs shows obvious efficacy for patients with cerebral thrombosis,and it can improve the platelet parameters and reduce the incidence of sequelae.It is worth popularizing and applying in clinical practice.