| 细胞凋亡与新生儿缺氧缺血性脑损伤的研究 |
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| 引用本文： | 朱欢,蒋犁.细胞凋亡与新生儿缺氧缺血性脑损伤的研究[J].中国妇幼健康研究,2005,16(6):374-377. |
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| 作者姓名： | 朱欢 蒋犁 |
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| 作者单位： | 东南大学临床医学院儿科,江苏,南京,210009;东南大学临床医学院儿科,江苏,南京,210009 |
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| 摘 要： | 该文主要阐述细胞凋亡与新生儿缺氧缺血性脑损伤的关系,提出细胞凋亡机制在缺氧缺血性脑损伤中的重要性。通过对半胱氨酸蛋白酶家族在细胞凋亡中所起作用的了解,具体阐述两条依赖半胱氨酸蛋白酶的凋亡途径,即线粒体介导的内源性途径和死亡受体介导的外源性途径。最后对半胱氨酸蛋白酶抑制剂用于将来的临床治疗提出挑战及前景。
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| 关 键 词： | 半胱氨酸蛋白酶 细胞凋亡 脑缺氧 脑缺血 |
| 文章编号： | 1008-2514(2005)06-0374-04 |
| 修稿时间： | 2005年9月19日 |
A research on relationship between apoptosis and neonatal hypoxic-ischemic brain damage |
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| ZHU Huan,JIANG Li.A research on relationship between apoptosis and neonatal hypoxic-ischemic brain damage[J].Chinese Journal of Maternal and Child Health Research,2005,16(6):374-377. |
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| Authors: | ZHU Huan JIANG Li |
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| Abstract: | In this review,we summarized relationship between apoptosis and neonatal hypoxic-ischemic brain damage(HIBD) and importance of apoptosis mechanism in HIBD.On the basis of understanding the roles of caspase family in apoptosis,The two caspase-dependent apoptotic pathways: the intrinsic apoptotic pathway by mitochondria and the extrinsic apoptotic pathway by death receptors were respectively explored.Finally,we pointed out the challenge and prospect in application of caspase inhibitors in the clinical treatment. |
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| Keywords: | caspase cellular apoptosis cerebral hypoxia cerebral ischemia |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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