| 胸苷酸合酶在胃癌的表达及临床病理学意义 |
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| 引用本文： | 卓丽娟,施作霖,高美钦,李燕辉,郑伟.胸苷酸合酶在胃癌的表达及临床病理学意义[J].福建医科大学学报,2003,37(2):174-176,T002. |
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| 作者姓名： | 卓丽娟 施作霖 高美钦 李燕辉 郑伟 |
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| 作者单位： | 1. 福建医科大学病理学系,福州,350004
2. 福建省立医院病理科,福州,350001 |
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| 摘 要： | 目的 观察胃癌中胸苷酸合酶(TS)的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系，探讨TS的临床病理学意义。方法 采用免疫组织化学SP法及计算机图像分析法测定70例胃癌组织(每例患者术后均经以5-氟尿嘧啶(5-FU)为主的化疗)及30例正常组织中TS的表达。结果 正常胃粘膜TS水平高于胃癌组织，高分化胃癌组的TS水平高于中低分化组，胃癌组织中TS表达水平与患者的年龄、性别及有否淋巴结转移无关；TS低表达组患者的预后优于TS高表达组。结论 胃癌组织中TS表达水平可作为患者对5-FU化疗疗效的判定指标。
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| 关 键 词： | 胃肿瘤 胸苷酸合酶 免疫组织化学 图像处理 计算机辅助 氟尿嘧啶 预后 |
| 文章编号： | 1672-4194(2003)02-0174-03 |
Expression of Thymidylate Synthase in Gastric Carcinoma and its Clinicopathological Significance |
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| ZHUO Li\|juan\,SHI Zuo\|lin\,GAO Mei\|qin\,LI Yan\|hui\,ZHENG Wei\.Expression of Thymidylate Synthase in Gastric Carcinoma and its Clinicopathological Significance[J].Journal of Fujian Medical University,2003,37(2):174-176,T002. |
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| Authors: | ZHUO Li\|juan\ SHI Zuo\|lin\ GAO Mei\|qin\ LI Yan\|hui\ ZHENG Wei\ |
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| Affiliation: | ZHUO Li\|juan\+1,SHI Zuo\|lin\+2,GAO Mei\|qin\+1,LI Yan\|hui\+2,ZHENG Wei\+1 1.Division of Pathology,Fujian Medical University,Fuzhou 350004,China 2.Department of Pathology,Fujian Province Hospital,Fuzhou 350001,China |
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| Abstract: | Objective To observe the expression of thymidylate synthase(TS) in gastric \{carcinoma\} and its relationships with clinicopathological characteristics and prognosis. Methods TS expression in 70 cases of gastric carcinoma and 30 cases of normal gastric mucosa was assessed by immunohistochemical staining technique and computer imaging analysis technique. Results The expression TS level of in normal gastric mucosa was higher than that in gastric carcinomas. The level of TS in well\|\{differentiated\} gastric carcinomas was higher than that in poor\|differentiated cases. There was an inverse association between the level of tumor TS expression and clinical prognosis. The level of TS showed no correlation with age, sex and lymph node metastases. Conclusion The expression of TS can serve as a 5\|FU\|based chemotherapeutic efficacy index in patients with gastric carcinoma. |
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| Keywords: | gastric tumor thymidylate synthase immunohistochemistry imaging management computer auxiliary fluorouracil prognosis |
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