| 病理性瘢痕发病机制研究进展 |
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| 引用本文： | 张娟娟,吕世军. 病理性瘢痕发病机制研究进展[J]. 医学综述, 2007, 13(8): 580-582 |
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| 作者姓名： | 张娟娟 吕世军 |
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| 作者单位： | 山东省潍坊医学院病理学教研室,山东,潍坊,261042 |
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| 摘 要： | 病理性瘢痕是人类真皮内特有的纤维代谢性疾病,以过量的纤维化和胶原蛋白沉积为特征,其发病机制复杂。成纤维细胞、肥大细胞、某些细胞因子在病理性瘢痕发病过程中起重要的作用。近年又发现病理性瘢痕组织中缝隙连接细胞间通讯受到抑制或阻断。缝隙连接可促进伤口愈合,尤其是胶原的成熟,它在病理性瘢痕中的作用将是今后的研究热点。
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| 关 键 词： | 病理性瘢痕 成纤维细胞 肥大细胞 细胞因子 缝隙连接 |
| 文章编号： | 1006-2084（1007）08-0580-03 |
| 收稿时间： | 2006-07-30 |
| 修稿时间： | 2006-07-302007-02-17 |
Pathogenesis Progress of Pathological Scar |
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| ZHANG Juan-juan,LV Shi-jun. Pathogenesis Progress of Pathological Scar[J]. Medical Recapitulate, 2007, 13(8): 580-582 |
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| Authors: | ZHANG Juan-juan LV Shi-jun |
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| Affiliation: | Department of Pathology, Weifang Medical College, Weifang 261042, China |
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| Abstract: | Pathological scar is a specific metabolic disease of human intracutaneous fiber.which is characterized by excessive fibrosis and collagen deposition.The pathogenesis of pathological scar is extremely complicated.Fibroblasts,mast cells and some cytokines may play great important roles in forming pathological scar.Recently,it is reported that gap junctional intercellular communication channel is inhibited or interdicted in pathological scar tissue.Gap junction can accelerate wound healing and espexially collagen maturation,whose effect in pathological scar will be the hot spot in future study. |
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| Keywords: | Pathological scar Fibroblast Mast cell Cytokine Gap junction |
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