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| 藏药佐太对西红花苷-1大鼠体内药动学的影响 | |
| 引用本文： | 李向阳,冯伟力,朱俊博,尼玛才让,格日力. 藏药佐太对西红花苷-1大鼠体内药动学的影响[J]. 中草药, 2009, 40(9): 1425-1428 |
| 作者姓名： | 李向阳 冯伟力 朱俊博 尼玛才让 格日力 |
| 作者单位： | 1. 青海大学医学院,药学系,青海,西宁,810001;青海大学高原医学研究中心,青海,西宁,810001 2. 青海大学医学院,药学系,青海,西宁,810001 3. 青海省藏医院,青海,西宁,810002 4. 青海大学高原医学研究中心,青海,西宁,810001 |
| 基金项目： | 国家中医药管理局中医药科学技术研究专项 |
| 摘 要： | 目的 探讨藏药佐太对西红花苷-1在大鼠体内药动学特征的影响.方法 对照组(连续ig生理盐水7 d)和实验组(连续ig佐太混悬液7 d或21 d)大鼠按5 mg/kg剂量im西红花苷-1后,采用反相高效液相色谱法测定给药后大鼠血浆中西红花苷-1的质量浓度,DAS 2.0软件计算各组大鼠西红花苷-1的药动学参数.结果 实验组大鼠分别按10 mg/(kg·d)连续ig佐太7 d和21 d后,西红花苷-1的药动学特征发生明显变化,AUC、C_(max)和MRT显著大于对照组,而CL和Vd显著小于对照组,并且随着佐太用药时间的延长,西红花苷-1的AUC增大.结论 给予佐太后西红花苷-1在大鼠体内的吸收显著增多、消除显著减慢. |
| 关 键 词： | 藏药 佐太 西红花苷-1 药动学 |
| 收稿时间： | 2009-01-20 |
Effect of Tibetan medicine Zuotai on in vivo pharmacokinetics of crocin-1 in rats |
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| LI Xiang-yang,FENG Wei-li,ZHU Jun-bo,NIMA Cai-rang and GE Ri-li. Effect of Tibetan medicine Zuotai on in vivo pharmacokinetics of crocin-1 in rats[J]. Chinese Traditional and Herbal Drugs, 2009, 40(9): 1425-1428 | |
| Authors: | LI Xiang-yang FENG Wei-li ZHU Jun-bo NIMA Cai-rang GE Ri-li |
| Affiliation: | Department of Pharmacy,Medical College of Qinghai University,Xining 810001,China;Research Center of High Altitude Medicine,Qinghai University,Xining 810001,China;Department of Pharmacy,Medical College of Qinghai University,Xining 810001,China;Department of Pharmacy,Medical College of Qinghai University,Xining 810001,China;Qinghai Tibetan Hospital,Xining 810002,China;Research Center of High Altitude Medicine,Qinghai University,Xining 810001,China |
| Abstract: | Objective To study the effect of Tibetan medicine Zuotai on in vivo pharmacokinetics of crocin-1 in rats.Methods After im injection of crocin-1(5 mg/kg)in control(continuously ig normal saline for 7 d)and expermental(continuously ig Zuotai suspension for 7 d or 21 d)rats,The plasma concentration of crocin-1 was determined by RP-HPLC,and plasma concentration-time data were analyzed by DAS 2.0 software to get the related pharmacokinetic parameters of crocin-1.Results After continuously parameters of crocin-1 changed significantly.The AUC,C_(max),and MRT were significantly greater in experimental rats than those in control rats,and the CL and Vd were significantly lower than those in control rats,and the AUC of crocin-1 was greater in the 21 d administration group than that in the 7 d administration group.Conclusion The result demonstrates that Tibetan medicine significantly affects the pharmacokinetics of crocin-1 in rats.After administration of Zuotai in rats,the absorption degree of crocin-1 iS significantly increased and the clearance rate is significantly decreased. |
| Keywords: | Tibetan medicine Zuotai crocin-1 pharmacokinetics |
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