| 烟碱和大脑功能障碍(英文) |
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| 引用本文： | Mihailescu S,Drucker-Colín R. 烟碱和大脑功能障碍(英文)[J]. Acta pharmacologica Sinica, 2000, 21(2): 97-104 |
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| 作者姓名： | Mihailescu S Drucker-Colín R |
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| 作者单位： | Departamento de Fisiología,Facultad de Medicina,Departamento de Fisiología,Facultad de Medicina,Depto de Neurociencias,Instituto de Fisiología Celular,Universidad Nacional Autónoma de México,Míxico |
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| 摘 要： | During the last decade, brain nicotinic acetylcholine receptors were extensively characterized from electrophys-iological and pharmacological points of view. These receptors play important roles in memory and cognition and participate in the pathogenesis of several brain disorders (Parkinson's and Alzheimer's diseases, Tourette's syndrome, schizophrenia, depression, attention deficit disorder) . In the same diseases, clinical studies showed that nicotine had beneficial effects, both as therapeutic and prophylactic agent. This review presents recent data concerning the structure and properties of neuronal nicotinic receptors, their involvement in the pathogenesis of various brain disorders and the beneficial effects of nicotine as therapeutic agent.
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| 关 键 词： | 烟碱 烟碱受体 帕金森病 阿尔采末病 多动秽语综合征 轻微脑损伤综合征 抑郁症 精神分裂症 |
Nicotine and brain disorders |
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| Mihailescu S,Drucker-Colín R. Nicotine and brain disorders[J]. Acta pharmacologica Sinica, 2000, 21(2): 97-104 |
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| Authors: | Mihailescu S Drucker-Colín R |
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| Affiliation: | Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México. |
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| Abstract: | During the last decade, brain nicotinic acetylcholine receptors were extensively characterized from electrophys-iological and pharmacological points of view. These receptors play important roles in memory and cognition and participate in the pathogenesis of several brain disorders (Parkinson's and Alzheimer's diseases, Tourette's syndrome, schizophrenia, depression, attention deficit disorder) . In the same diseases, clinical studies showed that nicotine had beneficial effects, both as therapeutic and prophylactic agent. This review presents recent data concerning the structure and properties of neuronal nicotinic receptors, their involvement in the pathogenesis of various brain disorders and the beneficial effects of nicotine as therapeutic agent. |
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| Keywords: | nicotine nicotinic receptors Parkinson disease Alzheimer disease Tourette syndrome attention deficit disorder with hyperactivity depression schizophrenia |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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