Swerilactones E-G, three unusual lactones from Swertia mileensis |
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| Authors: | Chang-An Geng Xue-Mei Zhang Zhi-Yong Jiang Jun Zhou Ji-Jun Chen |
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| Affiliation: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China
b Graduated School of Chinese Academy of Sciences, Beijing 100039, PR China |
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| Abstract: | Swerilactones E (1), F (2), and G (3), three unusual lactones with a phenyl group, were isolated from the traditional Chinese herb of Swertia mileensis. Their structures were determined based on extensive spectroscopic analysis and X-ray single crystal crystallography. Our anti-HBV assay on the Hep G 2.2.15 cell line in vitro showed that compounds 1 and 2 exhibited significant inhibitory activities against the secretion of HBsAg with IC50 of 0.22 and 0.70 mM and HBeAg with IC50 of 0.52 and >6.78 mM, respectively. |
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| Keywords: | Swertia mileensis Swerilactones E-G Secoiridoid aglycone Anti HBV activity |
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