厚壳贻贝多糖对葡聚糖硫酸钠诱导的结肠炎改善作用

为了探讨厚壳贻贝多糖(Mytilus coruscus polysaccharide,MP)对葡聚糖硫酸钠(dextran sodium sulfate,DSS)诱导的结肠炎的改善作用,试验设置空白组、模型组和MP组(300 mg/kg),在日常饮用水中给予质量分数3.5％DSS构建结肠炎模型,通过观察小鼠体态表征、肠...

Improving effect of mussel(Mytilus corusus)polysaccharide on dextran sodium sulfate-induced colitis

In this experiment,three groups:blank control group,model group and Mytilus coruscus polysaccharide(MP)group(300 mg/kg)were set up to explore whether MP could improve colitis induced by dextran sodium sulfate(DSS).After 3.5%DSS was given in daily drinking water,the drug was administrated by gavage,and the improvement effects of MP on colitis in mice were studied by observing the body characterization of mice,intestinal tissue morphology,and determination of intestinal and serum cytokines.The results showed that compared with the model group,the MP group could significantly alleviate the weight loss of mice,the shortening of the colon length(P<0.05),and reduce the disease activity index,improve inflammatory cell infiltration,glandular edema and goblet cell cut back.Compared with the model group,the superoxide dismutase(SOD)and glutathione reductase(GSH-Px)in the colon tissue of the MP group and the GSH-Px activity in the serum were significantly increased(P<0.05),and the SOD in the serum increased but there was no significant difference.The content of inflammatory factor tumor necrosis factor-ɑ(TNF-ɑ)in colon tissue and serum was significantly reduced(P<0.05),and the content of interleukin-6(IL-6)was reduced but there was no significant difference.The results proved that the Mytilus coruscus polysaccharide could improve the colitis induced by DSS to a certain extent.