中性粒细胞/淋巴细胞比值及单核细胞/淋巴细胞比值在多发性骨髓瘤患者中的预后意义

目的:研究中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)对多发性骨髓瘤(MM)患者预后的影响.方法:回顾性分析甘肃省人民医院收治的初发MM患者82例,根据血常规结果分别计算出NLR、MLR;根据患者工作特征曲线(ROC曲线)分别确定NLR和MLR的最佳截断点,将患者分为高NLR组、低NLR组和高M...

Value of Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma

Objective:To investigate the effect of neutrophil/lymphocyte ratio(NLR)and monocyte/lymphocyte ratio(MLR)in the valuation prognosis of patients with multiple myeloma(MM).Methods:The clinical data of 82 patients with initially diagnosed MM admitted to Gansu Provincial People's Hospital was analyzed retrospectively.NLR and MLR were calculated based on blood routine results respectively.The optimal cut-off point of NLR and MLR was determined according to the ROC curve,and the patients were divided into the high NLR/MLR group and the low NLR/MLR group.The general data,biochemical indicators and prognosis of the patients in each groups were compared respectively.The prognostic significance of the high NLR/MLR group and the low NLR/MLR group in patients between different treatment regimens and different clinical characteristics were analyzed.Risk stratification was designed based on NLR and high MLR as two risk factors,and the effect of risk factors,on the prognosis of MM patients were compared.Results:ROC curve analysis determined that the optimal cut-off point of NLR was 3.1(sensitivity 75%,specificity 70.7%)and the optimal cut-off point of MLR was 0.34(sensitivity 83.3%,specificity 53.4%).The lactate dehydrogenase(LDH)and mean platelet volume(MPV)were correlated to NLR and MLR(P<0.05).There were no significant difference in age,sex,serum calcium(Ca),β2-microglobulin(β2-MG),albumin(Alb),hemoglobin(Hb),platelet(PLT),serum creatinine(Cr),bone marrow plasma cell ratio and ISS stage between the two groups(P>0.05).The OS rate of patients with higher NLR and MLR was lower than those with low NLR and MLR and showed poor prognosis;Further analysis showed that there were statistically significant differences in OS time among patients with different MLR and NLR in the new drug treatment group and the traditional chemotherapy group,as well as patients in different age stratification groups,differentβ2-MG stratification groups and different serum creatinine stratification groups.Patients with 2 risk factors showed a poorer prognosis than those with 0-1 risk factor.Conclusion:Elevated NLR and MLR are associated with poor prognosis in MM patients and may serve as the cost-effective and readily available prognostic biomarkers.