| Effects of Angiotensin Ⅱ and ACE Inhibitor,Captopril on L-type Calcium Current and Sodium Current of Single Guinea Myocytes |
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| 引用本文： | 徐延敏,黄体钢,陈元禄.Effects of Angiotensin Ⅱ and ACE Inhibitor,Captopril on L-type Calcium Current and Sodium Current of Single Guinea Myocytes[J].岭南心血管病杂志(英文版),2002(2). |
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| 作者姓名： | 徐延敏 黄体钢 陈元禄 |
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| 作者单位： | The Institute of Cardiology of Tianjin，Tianjin 300211，P R China，The Institute of Cardiology of Tianjin，Tianjin 300211，P R China，The Institute of Cardiology of Tianjin，Tianjin 300211，P R China |
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| 摘 要： | Objectives To investigate effect of Angll, captopril on single guinea myocytes on L - type calcium current and sodium current. Methods Membrane patch clamp whole cell recording technique was used to investigate effect of angll, captopril on L - Ca maximum current density and sodium maximum current density. Resutls Angll increased the maximum current density compared with control after perfused 5 min, 357. 7 ±219. 7 Vs 279. 5± 240. 5 PA/PF, increase rate is 27. 9 %, the shape of current - voltage relationship curve was unchanged, peaked at 10 mv, indicated that angll increased L - Ca current density in voltage - dependent. After perfused with captopril, captopril angll 3, 5 min, L - Ca current was recorded, results suggest L - Ca maximum current density decreased significantly compared with control, in captopril group, 128. 4 ± 92. 6Vs286. 2 ± 89. 7, 66. 7±68. 3Vs 286. 2 ± 89. 7, respectively, rate of inhibition is 55. 1 %, 76. 6 %, respectively. L - Ca current further decreased in captopril pe
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| 关 键 词： | Membrane patch clamp IL - Ca current Ⅰ Na - current Angiotensin Ⅱ Captopril |
Effects of Angiotensin n and ACE Inhibitor, Captopril on L - type Calcium Current and Sodium Current of Single Guinea Myocytes |
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| XU Yanmin HUANG Tigang CHEN Yuanlu
The Institute of Cardiology of Tianjin,Tianjin ,P R China.Effects of Angiotensin n and ACE Inhibitor, Captopril on L - type Calcium Current and Sodium Current of Single Guinea Myocytes[J].South China Journal of Cardiology,2002(2). |
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| Authors: | XU Yanmin HUANG Tigang CHEN Yuanlu
The Institute of Cardiology of Tianjin Tianjin P R China |
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| Affiliation: | XU Yanmin HUANG Tigang CHEN Yuanlu
The Institute of Cardiology of Tianjin,Tianjin 300211,P R China |
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