神经生长因子防治爆震性聋的近期疗效观察

目的 观察神经生长因子(nerve growth factor，NGF)防治爆震性聋的临床效果。方法 参加实弹演习的炮手125例，分防治组48例(射击前2周至射击后2周肌肉注射NGF)、治疗组43例(射击后1—14d肌肉注射NGF)和对照组34例(不注射NGF)。测定射击前，射击后1，7和14d纯音听阈。结果 爆震后1d：防治组仅1例(2．1％)出现听阈提高(为轻度聋)，治疗组有3例听阈提高(7．0％，其中2例轻度聋，1例为中度聋)，对照组有6例听阈提高(17．6％，并有重度听力异常)；爆震后7d：防治组1例及治疗组中2例轻度听力异常者听力均恢复正常，治疗组中1例中度者转为轻度；14d后：治疗组听力全部恢复正常，而对照组中无听力好转者。结论 神经生长因子对防治爆震性聋有积极作用。

The clinical study of the effects of nerve growth factor on blast exposure hearing damage

Objective To study the clinical effects of nerve growth factor (NGF) on blast exposure hearing damage. Methods 125 soldiers were randomized into three groups: the prevention and cure group (48 cases, NGF were muscle injected 14 d before and after exposure); the cure group (43 cases, NGF were muscle injected 1 day to 14 after exposure); the control group (34 cases, with no drug). The pure-tone audiometry (PTA) were carried out before exposure and 1, 7,14 d after exposure. Results The PTA shows that 1d after exposure: 1 case had slight hearing damage in the prevention and cure group, 3 cases had hearing damage (2 cases were slight, 1 case was moderate) in the cure group, 6 cases had hearing damage ( had severe hearing damage) in the control group; 7d after exposure: the slight hearing damage in the prevention and cure group and in cure group were recovery, the moderate hearing damage in cure group was conversion to slight,~14 d after exposure recovery, the hearing damage did not recover in the control group. The difference was significant.Conclusions NGF can protect cochlear damage aginst blast exposure.