| 有机锡2-[(1,2,4-三唑-1-基)甲基硫代]苯甲酸酯的合成与生物活性 |
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| 引用本文： | 张晓燕,杨光,张俊,曾广同,唐良富.有机锡2-[(1,2,4-三唑-1-基)甲基硫代]苯甲酸酯的合成与生物活性[J].高等学校化学学报,2010,31(6):1162-1166. |
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| 作者姓名： | 张晓燕 杨光 张俊 曾广同 唐良富 |
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| 作者单位： | 南开大学化学系, 元素有机化学国家重点实验室, 天津 300071 |
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| 摘 要： | 通过硫代水杨酸与(1-氯甲基)-1,2,4-三唑盐酸盐在碱性条件下的反应, 合成了2-(1,2,4-三唑-1-基)甲基硫代]苯甲酸. 利用该酸与(R3Sn)2O(R=Et, n-Bu, Ph), Cy3SnOH(Cy为环己基)或Et2SnO反应, 得到了5个有机锡羧酸酯. 用X射线单晶衍射测定了三正丁基锡2-(1,2,4-三唑-1-基)甲基硫代]苯甲酸酯的晶体结构. 在该化合物中, 锡为五配位的三角双锥结构. 该化合物通过三唑四位氮原子与锡配位, 形成一维链状配位高分子. 初步的生物活性测试结果表明, 所有的有机锡化合物都表现出了明显的抗真菌活性.
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| 关 键 词： | 有机锡羧酸酯 1 2 4-三唑 晶体结构 抗真菌活性 |
| 收稿时间： | 2009-08-04 |
Synthesis and Biological Activities of Organotin 2-[(1,2,4-Triazol-1-yl)methylthio]benzoates |
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| ZHANG Xiao-Yan,YANG Guang,ZHANG Jun,ZENG Guang-Tong,TANG Liang-Fu.Synthesis and Biological Activities of Organotin 2-[(1,2,4-Triazol-1-yl)methylthio]benzoates[J].Chemical Research In Chinese Universities,2010,31(6):1162-1166. |
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| Authors: | ZHANG Xiao-Yan YANG Guang ZHANG Jun ZENG Guang-Tong TANG Liang-Fu |
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| Affiliation: | Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Triazole and its derivatives have attracted broad attention owing to their good coordination ability as well as extensive biological activities.In this paper,a new carboxylic acid with triazole moiety,namely 2-(1,2,4-triazol-1-yl)methylthio]benzoic acid,was synthesized by the reaction of thiosalicylic acid with 1-chloromethyl-1,2,4-triazole-HCl.Five organotin 2-(1,2,4-triazol-1-yl)methylthio]benzoates were obtained upon treatment this acid with(R3Sn)2O(R=Et,n-Bu,Ph),Cy3SnOH(Cy=cyclohexyl) and Et2SnO.The m... |
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| Keywords: | Organotin carboxylate 1 2 4-Triazole Crystal structure Antifungal activity |
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