Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet |
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Authors: | Yoshiaki Miyake Eriko Suzuki Satoko Ohya Syuichi Fukumoto Masanori Hiramitsu Kazuhiro Sakaida Toshihiko Osawa Yukio Furuichi |
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Affiliation: | Author Miyake is with Faculty of Human Wellness, Tokaigakuen Univ., Nagoya 468-8514, Japan. Authors Suzuki, Ohya, and Furuichi are with Laboratory of Nutrition Chemistry, Faculty of Bioresources, Mie Univ., Tsu 514-8507, Japan. Authors Fukumoto, Hiramitsu, and Sakaida are with Pokka Corp. Ltd., Nishikasugai-gun, Aichi 481-8515, Japan. Author Osawa is with Laboratory of Food and Biodynamics Graduate School of Bioagricultural Sciences, Nagoya Univ., Nagoya 464-8601, Japan. Direct inquiries to author Miyake (E-mail: ). |
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Abstract: | ABSTRACT: Eriocitrin (eriodictyol 7- O -β-rutinoside) is the main flavonoid in lemon fruit. In this study, eriocitrin was investigated for its lowering effect on serum and hepatic lipids in high-fat and high-cholesterol fed rats. Rats in the control group ( N = 6) were fed a 20% lard and 1% cholesterol diet for 21 d, and rats in the 0.35% eriocitrin group ( N = 6) and 0.70% eriocitrin group ( N = 6) were fed a diet supplemented with eriocitrin 0.35% and 0.70%, respectively. The content of hepatic total cholesterol and triglyceride in the eriocitrin group was no different from that of the control group. The total cholesterol, VLDL+LDL, triglyceride, and phospholipid in the serum of the 0.35% eriocitrin group showed significantly lower concentrations than the control group ( P < 0.05), although there was no difference in the HDL concentrations among the groups. The lowering effect of eriocitrin for serum total cholesterol was thought to be caused by a decrease in VLDL+LDL. The 0.35% eriocitrin group was shown to have a significant increase in excretion of fecal bile acid ( P < 0.05) and a tendency for enhanced hepatic m-RNA levels of LDL receptor in comparison with the control group. |
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Keywords: | eriocitrin lemon flavonoid lipid metabolism rat |
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