乳腺浸润性导管癌组织Ki-67和p53蛋白的表达及其临床意义

目的检测乳腺浸润性导管癌组织中Ki-67和p53的表达，并探讨其表达在乳腺浸润性导管癌中的临床意义。方法免疫组化S-P法检测乳腺浸润性导管癌组织及乳腺良性病变组织中Ki-67和053的表达，统计学分析Ki-67和053表达与乳腺浸润性导管癌患者临床病理特征及预后的关系。结果Ki-67和p53蛋白在乳腺浸润性导管癌中均呈高表达，42例组织中Ki-67阳性表达率78．6％，p53为38．1％，乳腺良性病变中Ki-67无表达，2例053阳性表达，两组存在显著性差异；Ki-67与p53的表达率随浸润性导管癌TNN分期的增高而上升，另外Ki-67表达与浸润性导管癌的大小密切相关。结论Ki-67和p53蛋白与浸润性导管癌TNM分期密切相关，对其进行联合检测可有助于浸润性导管癌的预后判断。

Expression and clinical significance of Ki-67and p53 in breast invasive ductal carcinoma

Objective To investigate the expression and clinical significance of Ki - 67 and p53 in breast invasive ductal carcinoma（IDC）. Methods Immunohisto chemical SP method was applied to detect the expression of Ki -67 and p53 protein in 42 cases with IDC and 18 cases with benign breast lesions,statistical analysis was performed to correlate the expression of Ki - 67 and p53 with their clinical parameters. Results The positive expression percentage of Ki - 67 and p53 was significantly higher in IDC cases than that in benign lesions cases（78.6% VS 0,38.1 VS 5.6% ）. There was significant association between Ki - 67,p53 expression and TNM staging,Ki -67 and p53 increasing correlated with higher TNM staging. There was another significant asso- ciation between Ki -67 expression and tumor size. Conclusion The findings suggest that the positive expression of Ki -67 and p53in IDC make a closed correlation with TNM staging,Co -determining the expression of Ki -67 and p53in IDC ease may play an important role in prediction of the IDC prognosis.