| 载Bi2S3液态氟碳纳米粒的制备及体外多功能显影 |
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| 引用本文： | 何敏瑜,冉海涛,周頔,马明,王志刚.载Bi2S3液态氟碳纳米粒的制备及体外多功能显影[J].中国介入影像与治疗学,2014,11(12):808-812. |
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| 作者姓名： | 何敏瑜 冉海涛 周頔 马明 王志刚 |
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| 作者单位： | 重庆医科大学超声影像学研究所, 重庆 400010;重庆医科大学超声影像学研究所, 重庆 400010;重庆医科大学附属第二医院超声科, 重庆 400010;重庆医科大学超声影像学研究所, 重庆 400010;中科院上海硅酸盐研究所, 上海 200050;重庆医科大学超声影像学研究所, 重庆 400010 |
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| 基金项目： | 重庆市高校创新团队计划(KJTD201303)、国家自然基金重点项目(81130025)。 |
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| 摘 要： | 目的制备新型载Bi2S3液态氟碳纳米粒,观察其特性及其体外多功能显影效果。方法采用旋转蒸发法制备载Bi2S3液态氟碳纳米粒(Bi2S3-PFH),检测其理化性质。对不同浓度Bi2S3-PFH纳米粒进行超声显像,并观察经低强度聚焦超声(LIFU)仪器辐照后的图像变化。对不同浓度Bi2S3-PFH纳米粒进行CT显像。结果 Bi2S3-PFH为棕色混悬液;显微镜下呈球形,平均粒径为(487.2±14.5)nm,Zeta电位为-(18.8±1.6)mV;随着纳米粒浓度的增加,体外超声信号强度增强,且经LIFU辐照后回声强度进一步增强。体外CT值呈明显的浓度依赖性增高。结论成功制备的新型载Bi2S3液态氟碳纳米粒可用于体外超声、CT显影。
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| 关 键 词： | 造影剂 纳米颗粒 超声 体层摄影术 X线计算机 |
| 收稿时间： | 2014/6/18 0:00:00 |
| 修稿时间： | 2014/8/20 0:00:00 |
Preparation of perfluorohexane-encapsulated bismuth sulfide nanoparticles and multifunctional imaging in vitro |
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| HE Min-yu,RAN Hai-tao,ZHOU Di,MA Ming and WANG Zhi-gang.Preparation of perfluorohexane-encapsulated bismuth sulfide nanoparticles and multifunctional imaging in vitro[J].Chinese Journal of Interventional Imaging and Therapy,2014,11(12):808-812. |
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| Authors: | HE Min-yu RAN Hai-tao ZHOU Di MA Ming and WANG Zhi-gang |
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| Affiliation: | Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China;Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China;Department of Ultrasonography, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China;Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China;Shanghai Institute of Chinese Academy of Sciences, Shanghai 200050, China;Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, China |
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| Abstract: | Objective To prepare a new perfluorohexane-encapsulated bismuth sulfide nanoparticles（Bi2S3-PFH）and observe its physical characteristics and multifunctional imaging in vitro.Methods Bi2S3-PFH nanoparticles were prepared by vacuum rotary evaporation.Physical and chemical properties were assessed.The ultrasound imaging were observed in vitro after using low intensity focused ultrasound（LIFU）,and the CT examination was also performed in different concentrations of Bi2S3-PFH.Results Bi2S3-PFH nanoparticles was brown suspension in appearance,it is spherical,with average particle size was（487.2±14.5）nm and potential was-（18.8±1.6）mV.The ultrasonic signal intensity enhanced with Bi2S3-PFH concentration increased in vitro,and the ultrasonic signal intensity also enhanced after using LIFU.CT value increased depend on concentrations in vitro.Conclusion A new multifunctional contrast agents perfluorohexane-encapsulated bismuth sulfide nanoparticles is successfully prepared which can use in ultrasound,CT imaging in vitro. |
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| Keywords: | Contrast media Nano particle Ultrasound Tomography X-ray computed |
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