细胞间粘附分子-1在创伤性急性肺损伤中的作用

目的：探讨细胞间粘附分子－１（ＩＣＡＭ－１）在急性肺损伤（ＡＬＩ）中的作用。方法：运用兔胸部撞击法自制创伤性急性肺损伤模型，动态检测血浆中可溶性ＩＣＡＭ－１浓度变化，观察抗ＩＣＡＭ－１抗体对创伤后兔肺顺应性、呼吸指数及氧合指数的影响及病理变化。结果：在兔胸部撞击后１ｈ肺顺应性即显著降低，４ｈ后血浆中ＩＣＡＭ－１上升到（３９００±１４）μｇ·Ｌ１，并在２４ｈ内维持在较高水平。抗ＩＣＡＭ－１抗体能显著降低血浆中ＩＣＡＭ－１含量，改善肺顺应性，降低呼吸指数，提高氧合指数，减少肺泡内炎症细胞渗出，从而改善肺功能。结论：急性肺损伤时ＩＣＡＭ－１表达增加，抑制或阻断ＩＣＡＭ－１表达有助于减轻急性肺损伤。

The Role of Intercellular Adhesion Molecular1 in Acute Lung Injury

Objective: The purpose of this research was to investigate the rule of intercellular adhesion molecular1 (ICAM1) in acute traumatic lung injury. Methods: Sixteen rabbits were divided into two groups to creat acute lung injury model by direct chest attack.The levels of soluble ICAM1 (slCAM1) in plasma were evaluated in both groups.The effects of antiICAM1 antibody on the lung compliance,respiratory index(RI),and oxygenation index(OI) were studied.The pathologic changes were also observed. Results: Lung compliance reduced at 1h after chest trauma,and sICAM1 rose to (390.014.0)gL1 in control group at 4h after trauma,kept at a higher level for 24h.The experimental group pretreated with antiICAM1 antibody had a lower respiratory index and a higher oxygenization index.Alveolar neutrophil emigration was inhibited in experimental group. Conclusion: ICAM1 expression was upregulated during acute lung injury.AntiICAM1 antibody could improve injuried lung compliance caused by trauma with lower RI and OI.